Ordering Recommendation

Monitor patient adherence.


Qualitative High Performance Liquid Chromatography-Tandem Mass Spectrometry




5-8 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Plain red, lavender (EDTA), or pink (K2EDTA).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP standard transport tube. (Min: 0.5 mL)
Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.

Storage/Transport Temperature

Refrigerated. Also acceptable: Room temperature or frozen.

Unacceptable Conditions

Separator tubes.


Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: 11 months

Reference Interval

By report

Interpretive Data

By report

Compliance Category

Performed by non-ARUP Laboratory


Peak serum levels are recommended when monitoring patients because the level in the blood drops so rapidly that many negative results are found at the trough. The peak occurs at 40 to 90 minutes post dose.

Hotline History


CPT Codes

80373 (Alt code: G0480)


Component Test Code* Component Chart Name LOINC
2014687 Tramadol, Serum/Plasma 12437-0
2014688 O-Desmethyltramadol, Serum/Plasma 73973-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • O-Desmethyltramadol
  • Ultram
  • Ultrex
Tramadol and Metabolite, Quantitative, Serum or Plasma

National Medical Services (NMS)