Reference IntervalNormal range/expected value(s) for a specific disease state. May also include abnormal ranges.
Reports include age appropriate reference intervals and interpretation.
Test Number
Components
Age: 2-18 years old
Age 18-69 years old
Absolute alpha/beta TCR+ DNT
0-46 (cells/uL)
0-32 (cells/uL)
Absolute alpha/beta TCR+ DNT B220+
0-5 (cells/uL)
0-6 (cells/uL)
% alpha/beta TCR+ DNT
0-3 (%)
0-2 (%)
% alpha/beta TCR+ DNT B220+
0-0.3 (%)
0-0.4 (%)
Interpretive DataBackground information for test. May include disease information, patient result explanation, recommendations, details of testing, associated diseases, explanation of possible patient results.
Reported percentages reflect percentage of CD3 positive lymphocytes. The hallmark for a diagnosis of Autoimmune Lymphoproliferative Syndrome (ALPS) is an increased concentration of CD3+ T-cells negative for CD4 and CD8 (double-negative T-cells [DNT]) and positive for the alpha/beta T-cell receptor (TCR). B220 expression on alpha/beta TCR+DNT cells is a sensitive and specific marker for ALPS and is associated with mutations in the FAS gene.
Abnormal results should be correlated with clinical history and confirmed by additional testing for defective in vitro lymphocyte apoptosis and for mutations in the FAS gene.
Compliance Category
Laboratory Developed Test (LDT)
NoteAdditional information related to the test.
Hotline History
N/A
CPT CodesThe American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
AliasesOther names that describe the test. Synonyms.
Alpha/Beta Double-Negative T-Cells for Autoimmune Lymphoproliferative Syndrome
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