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Thiopurine Metabolites by LC-MS/MS
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Ordering Recommendation
Phenotype test used to optimize therapy for patients who are taking thiopurine drugs. Thiopurine metabolite concentrations are identified to assess therapeutic and toxic concentrations. If thiopurine therapy has not been initiated, order Thiopurine Methyltransferase, RBC (0092066).
Mnemonic
Methodology
Quantitative Liquid Chromatography/Tandem Mass Spectrometry
Performed
Varies
Reported
3-5 days
New York DOH Approval Status
Specimen Required
Lavender (K2 or K3EDTA).
Transport 3 mL whole blood in the original collection tube. (Min: 1.5 mL)
Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.
Refrigerated.
Hemolyzed specimens.
Ambient: 24 hours; Refrigerated: 8 days; Frozen: Unacceptable
Reference Interval
By report
Interpretive Data
Performed by non-ARUP Laboratory
Note
Hotline History
CPT Codes
80299
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2014485 | 6-Thioguanine | 32660-3 |
| 2014486 | 6-Methylmercaptopurine | 32654-6 |
Aliases
- 6 Methyl Mercaptopurine
- 6-Mercaptopurine
- 6-Methylmercaptopurine
- 6-MMP
- 6-MMPN
- 6-MP
- 6-TG
- 6-TGN
- 6-Thioguanine
- 6MMP
- 6MMPN
- 6MP
- 6TG
- 6TGN
- AZA
- FPMET
- Imuran Metabolite
- Mercaptopurine
- Methylmercaptopurine
- Purine antimetabolites
- Purinethol
- THIO
- Thioguanine
- Thiopurine
- Thiopurine Metabolites
- TPMT
- TPRBC
Mayo Clinic Laboratories
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