Detect the presence of predominant carbapenemase genes (blaKPC, blaNDM, blaVIM, blaOXA-48, blaIMP) responsible for resistance to carbapenem and other beta-lactam antibiotics.
Qualitative Polymerase Chain Reaction
New York DOH Approval Status
Actively growing Enterobacteriaceae, Pseudomonas aeruginosa, or Acinetobacter baumannii in pure culture.
Transport sealed container with pure culture on agar slant/bacterial transport media. Place each specimen in an individually sealed bag.
Mixed cultures or nonviable organisms.
Isolate identification (for cultures) and specimen source required.
Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable
This assay detects five carbapenemase gene families (blaKPC, blaNDM, blaOXA-48, blaVIM, blaIMP) encoding enzymes that may confer resistance to carbapenem and other beta-lactam antibiotics. This assay is intended for use as an aid to infection control in the detection of carbapenem-resistant bacteria and is not intended to guide or monitor treatment of infection. A negative result does not exclude the presence of other resistance mechanisms or assay-specific nucleic acid in concentrations below the level of detection.
An additional processing fee will be billed for all isolates not submitted in pure culture, as indicated in the specimen requirements.
If species identification is not provided, identification will be performed at ARUP. Additional charges apply.
This assay will generate a negative IMP result when testing samples containing IMP-7, IMP-13 or IMP-14 gene sequences, and may detect IMP-4 at reduced sensitivity.
|Component Test Code*||Component Chart Name||LOINC|
|2014278||KPC gene by PCR||49617-4|
|2014279||NDM gene by PCR||73982-1|
|2014280||OXA-48 gene by PCR||63368-5|
|2014281||VIM gene by PCR||63368-5|
|2014282||IMP gene by PCR||63368-5|
- Klebsiella pneumoniae carbapenemase
- MA KPCPCR
- multi-drug resistance
- NewDelhi metallo-B-lactamase
- resistance mechanism