Ordering Recommendation

May be useful in immunization/vaccination trials or may aid in the clinical diagnosis of diseases strongly associated with the HLA-DP locus.


Polymerase Chain Reaction/Sequence Specific Oligonucleotide Probe Hybridization




3-7 days

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation

Lavender (EDTA), Pink (K2EDTA), or Yellow (ACD Solution A or B).

Specimen Preparation

Transport 5 mL whole blood. (Min: 3 mL)

Storage/Transport Temperature


Unacceptable Conditions

Green (Sodium or Lithium Heparin) tubes.


Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Background Information for HLA-DP Genotyping:
For immunization/vaccination trials or to aid the clinical diagnosis of diseases strongly associated with the HLA-DP locus.
Methodology: PCR followed by Sequence Specific Oligonucleotide Probe Hybridization of HLA-DP locus.
Analytical Sensitivity & Specificity: Medium to high resolution of HLA-DP locus.
Limitations: The presence of a disease-associated HLA combination does not establish a diagnosis. If fewer than 2 alleles are reported for a locus, the patient is likely homozygous. Rare diagnostic errors can occur due to primer or probe site mutations. This test is not sufficient for comprehensive HLA evaluation for clinical hematopoietic stem cell transplantation; for pre-transplant allele matching, consider HLA Class I (ABC) by Next Generation Sequencing (ARUP test code 2011264) and/or HLA Class II (DRB1 and DQB1) by Next Generation Sequencing (ARUP test code 2011272).
Occasionally the specific allele cannot be determined; in this case, the most likely allele assignment is made followed by a sequence of letters indicating other possible allele assignments. Interpretation of allele codes can be found at https://bioinformatics.bethematchclinical.org/hla/alpha.v3.html.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com.

No compliance statements are in use for this test.


Order this test for single antigen HLA-DP identification.

Hotline History
Component Test Code* Component Chart Name LOINC
2014074 HLA Class II, Locus DPA1*, Allele 1 59018-2
2014075 HLA Class II, Locus DPA1*, Allele 2 59018-2
2014076 HLA Class II, Locus DPB1*, Allele 1 59017-4
2014077 HLA Class II, Locus DPB1*, Allele 2 59017-4
2014078 HLA-DP Genotyping Interpretation 50398-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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HLA-DP Genotyping