Ordering Recommendation
Use for patients whose symptoms began, or whose documented exposure occurred, ≥14 days prior to testing. Use as follow-up for patients with negative serum and urine results from molecular testing performed <14 days after symptom onset.
Mnemonic
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon, Wed, Fri
Reported
1-6 days
New York DOH Approval Status
Specimen Required
Serum Separator Tube (SST).
Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1.0 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimen plainly as "acute or convalescent."
Refrigerated.
Bacterially contaminated, heat-inactivated, hemolyzed, icteric, lipemic, or turbid specimens.
Submit patient history.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
Negative
Interpretive Data
The possibility of false-positive or false-negative results must be considered. RT-PCR testing on both a serum and urine specimen is recommended by the Centers for Disease Control and Prevention (CDC) to rule out false-negative IgM results in patients experiencing symptoms for less than 2 weeks. Specimens collected for IgM testing greater than or equal to 2 weeks after symptom onset do not require any additional testing. For more information, please review the current clinical guidelines for Zika virus testing at: www.cdc.gov/zika/.
FDA
Note
If the result is "Presumptive Zika," then Zika IgM Ab Capture (MAC) Confirmation (ARUP test code 3001904) will be added at no additional charge.
Hotline History
CPT Codes
86794
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2014017 | Zika Virus IgM Ab Capture (MAC), ELISA | 80824-6 |
2014018 | Pregnant? | 66174-4 |
2014019 | Relevant Zika virus Exposure? | 92944-8 |
2014020 | Symptoms consistent with Zika virus? | 75325-1 |