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Zika Virus IgM Antibody Capture (MAC), by ELISA
Ordering Recommendation
Use for patients whose symptoms began, or whose documented exposure occurred, ≥14 days prior to testing. Use as follow-up for patients with negative serum and urine results from molecular testing performed <14 days after symptom onset.
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon, Wed, Fri
Reported
1-6 days
New York DOH Approval Status
Specimen Required
Serum Separator Tube (SST).
Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1.0 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimen plainly as "acute or convalescent."
Refrigerated.
Bacterially contaminated, heat-inactivated, hemolyzed, icteric, lipemic, or turbid specimens.
Submit patient history.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
Negative
Interpretive Data
The possibility of false-positive or false-negative results must be considered. RT-PCR testing on both a serum and urine specimen is recommended by the Centers for Disease Control and Prevention (CDC) to rule out false-negative IgM results in patients experiencing symptoms for less than 2 weeks. Specimens collected for IgM testing greater than or equal to 2 weeks after symptom onset do not require any additional testing. For more information, please review the current clinical guidelines for Zika virus testing at: www.cdc.gov/zika/.
FDA
Note
Hotline History
CPT Codes
86794
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2014017 | Zika Virus IgM Ab Capture (MAC), ELISA | 80824-6 |
| 2014018 | Pregnant? | 66174-4 |
| 2014019 | Relevant Zika virus Exposure? | 92944-8 |
| 2014020 | Symptoms consistent with Zika virus? | 75325-1 |
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