Ordering Recommendation

Not recommended for evaluation of general hearing loss.

Mnemonic
HSP
Methodology

Qualitative Immunoblot

Performed

Thu

Reported

1-8 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum Separator Tube (SST) or Plain Red.

Specimen Preparation

Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Urine or plasma. Heat inactivated and contaminated specimens.

Remarks
Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

Negative

Interpretive Data

The presence of HSP70 IgG antibodies may be useful in predicting corticosteroid responsiveness in a subset of patients with autoimmune inner ear disease (AIED) characterized by idiopathic rapidly progressive sensorineural hearing loss (SNHL). HSP70 IgG antibodies are also associated with a number of autoimmune diseases and have also been reported in apparently healthy individuals. A negative result does not rule out response to treatment or to a diagnosis of AIED.

Compliance Statement D: For laboratory tests using a manufactured RUO kit. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
N/A
Components
Component Test Code* Component Chart Name LOINC
2013591 Heat Shock Protein 70, IgG by Immunoblot 43597-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 68KD
Heat Shock Protein 70, IgG by Immunoblot