Ordering Recommendation

Recommended test to confirm a diagnosis of hereditary gastrointestinal (GI) cancer in individuals with a personal or family history of GI cancer and/or polyposis. When a relative has a previously identified pathogenic variant, see Familial Mutation, Targeted Sequencing (2001961).

Mnemonic
GICAN PAN
Methodology

Massively Parallel Sequencing/Exonic Oligonucleotide-based CGH Microarray/Sequencing/Multiplex Ligation-dependent Probe Amplification

Performed

Varies

Reported

3-6 weeks

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Lavender (EDTA) or Yellow (ACD Solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Statement C: For human genetic inheritable conditions and mutations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Note

Genes Tested: APC, AXIN2**, BMPR1A, CDH1, CHEK2*, EPCAM****, MLH1, MSH2, MSH3**, MSH6, MUTYH, NTHL1, PMS2, POLD1, POLE, PTEN, SDHB, SDHC*, SDHD*, SMAD4, STK11, TP53
 
* One or more exons are not covered by sequencing for the indicated gene; see Additional Technical Information.
** Deletion/duplication detection is not available for this gene.
**** Deletion/duplication only; sequencing is not available for this gene.

Hotline History
N/A
Components
Component Test Code* Component Chart Name LOINC
2010199 Gastrointestinal Cancer Panel - Spcmn 31208-2
2013450 Gastrointestinal Cancer Panel - Interp 41103-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Cowden syndrome
  • Familial Adenomatous Polyposis (FAP)
  • Hereditary Diffuse Gastric Cancer (HDGC)
  • Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
  • Hereditary Paraganglioma Pheochromocytoma syndrome
  • Juvenile polyposis
  • Juvenile Polyposis syndrome (JPS)
  • Li-Fraumeni syndrome (LFS)
  • Lynch
  • Lynch syndrome
  • MUTYH-associated polyposis (MAP)
  • Peutz Jegher syndrome (PJS)
Hereditary Gastrointestinal Cancer Panel, Sequencing and Deletion/Duplication