Ordering RecommendationRecommendations when to order or not order the test. May include related or preferred tests.
Optimize drug therapy and monitor patient adherence.
MnemonicUnique test identifier.
CLOZAP SP
MethodologyProcess(es) used to perform the test.
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
PerformedDays of the week the test is performed.
Sun-Sat
ReportedExpected turnaround time for a result, beginning when ARUP has received the specimen.
1-3 days
New York DOH Approval StatusIndicates test has been approved by the New York State Department of Health.
This test is New York DOH approved.
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Collect
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Remarks
Stability
After separation from cells: Ambient: 5 weeks; Refrigerated: 2 months; Frozen: 2 months
Reference IntervalNormal range/expected value(s) for a specific disease state. May also include abnormal ranges.
Therapeutic Range
Not well established
Toxic Level
Total Clozapine and Metabolites: Greater than or equal to 1500 ng/mL
Interpretive DataBackground information for test. May include disease information, patient result explanation, recommendations, details of testing, associated diseases, explanation of possible patient results.
Therapeutic ranges are not well established. Clozapine is metabolized to norclozapine and clozapine-N-oxide. Clozapine concentrations between 100 and 700 ng/mL may correlate more with clinical response; however, non-responsiveness may also occur within this range. For refractory schizophrenia, clozapine concentrations greater than 350 ng/mL are suggested to achieve a therapeutic response.
Toxicity: Adverse effects to clozapine therapy may include tachycardia, drowsiness, hypotension, and seizures.
Therapeutic and toxic ranges are not well established in children.
Compliance Category
Laboratory Developed Test (LDT)
NoteAdditional information related to the test.
Hotline History
N/A
CPT CodesThe American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
AliasesOther names that describe the test. Synonyms.
Clopine
Clozaril
Denzapine
FazaClo
Versacloz
Zaponex
Clozapine and Metabolites, Serum or Plasma, Quantitative
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