Human Immunodeficiency Virus (HIV) Combo Antigen/Antibody (HIV-1/O/2) by CIA with Reflex to HIV-1/HIV-2 Antibody Differentiation, Supplemental
• This 4th generation test screens for HIV-1 p24 antigen and antibodies to HIV-1 (groups M and O) and HIV-2. Repeatedly reactive HIV-1, 2 antigen/antibody screening results will reflex to an HIV-1/HIV-2 antibody differentiation test.
•This test does not complete the 2014 CDC Recommended Algorithm for Laboratory Diagnosis of HIV Infection. Preferred test is Human Immunodeficiency Virus (HIV) Combo Antigen/Antibody (HIV-1/O/2) by CIA, Reflexive Panel (2012674).
Qualitative Chemiluminescent Immunoassay (CLIA)/Qualitative Immunoassay
New York DOH Approval Status
Serum separator tube (SST). Also acceptable: Lavender (EDTA) or pink (K2EDTA).
Separate from cells ASAP or within 2 hours of collection. Transfer 1.5 mL serum into an ARUP standard transport tube. (Min: 0.75 mL) Remove particulate material.
Specimens containing particulate material. Severely hemolyzed or heat-inactivated specimens.
After separation from cells: Ambient: 24 hours; Refrigerated: 7 days; Frozen: 8 months (avoid repeated freeze/thaw cycles)
|HIV 1,2 Combo Antigen/Antibody||Negative|
This test should not be used for blood donor screening, associated reentry protocols, or for screening human cell, tissues, and cellular- and tissue-based products (HCT/P).
The fourth-generation screen test is for the simultaneous qualitative detection of human immunodeficiency virus type 1 (HIV-1) p24 antigen and antibodies to HIV type 1 (HIV-1 groups M and O) and HIV type 2 (HIV-2). Results of the screen cannot be used to distinguish between the presence of HIV-1 p24 antigen, HIV-1 antibody, or HIV-2 antibody.
The reflexed HIV-1/ HIV-2 antibody differentiation test discriminates between HIV-1 and HIV-2 antibodies. Results for each type are reported.
If the HIV-1,2 combo antigen/antibody screen is repeatedly reactive, then the HIV-1/ HIV-2 antibody differentiation test will be performed. Additional charges apply. A recommendation to order further testing on a separate specimen for HIV-1 nucleic acid will be made for certain results. This multitest algorithm is recommended by the Centers for Disease Control and Prevention (CDC) and was adopted by the Clinical Laboratory Standards Institute (CLSI) for the diagnosis of HIV.
87389; if reflexed, add 86701; 86702
|Component Test Code*||Component Chart Name||LOINC|
|2012675||HIV 1,2 Combo Antigen/Antibody||56888-1|
- 4th generation
- Fourth generation HIV
- HIV 1,2 Combo Antigen/Antibody
- HIV Diagnosis
- HIV Geenius
- HIV-1 & 2 Antibody Differentiation
- HIV-1 Antibody by Geenius
- HIV-1,2 Combo Antigen/Antibody
- HIV-2 Antibody by Geenius
- Human Immunodeficiency Virus (HIV) Combo Antigen/Antibody