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Human Immunodeficiency Virus Types 1 and 2 (HIV-1/2) Antibody Differentiation, Supplemental

HIV AB SUP
Example Reports
Indeterminate
Negative
Positive

Ordering Recommendation

Use only when patient has a repeatedly reactive third- or fourth-generation HIV screen test result. This test discriminates between HIV-1 and HIV-2 antibodies.

Methodology

Qualitative Immunoassay

Performed

Varies

Reported

1-2 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA) or pink (K2EDTA). Also acceptable: Serum separator tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma into an ARUP standard transport tube dedicated only for HIV testing. (Min: 0.5 mL) Remove particulate material.

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Specimens containing particulate material. Severely hemolyzed or heat-inactivated specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 7 days; Frozen: 8 months (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
 Components
 Reference Interval
  HIV-1 Antibody Negative
  HIV-2 Antibody Negative

Interpretive Data

This test should not be used for blood donor screening, associated reentry protocols, or for screening human cells, tissues, and cellular- and tissue-based products (HCT/P).

Compliance Category

FDA

Note

For use ONLY when patient has a repeatedly reactive third- or fourth-generation HIV screen test result. This test discriminates between HIV-1 and HIV-2 antibodies. Results for each type are reported. This test is for use as the antibody differentiation test in the specific multitest algorithm. If results are negative or indeterminate, this test does NOT reflex to a nucleic acid test.

A multitest algorithm is recommended by the Centers for Disease Control and Prevention (CDC) and the Clinical Laboratory Standards Institute (CLSI) for the diagnosis of HIV (refer to https://arupconsult.com/content/human-immunodeficiency-virus).

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/21/2023
X
N/A

CPT Codes

86701; 86702

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Components

Component Test Code* Component Chart Name LOINC
2012670 HIV-1/2 Ab Differentiation Immunoassay 77202-0
2012671 HIV-1 Antibody 68961-2
2012672 HIV-2 Antibody 81641-3
2012673 HIV Serologic Interpretation 80203-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Geenius
  • HIV Diagnosis
  • HIV Multispot
  • HIV-1 & 2 Antibody Differentiation
  • HIV-1 and HIV-2 Antibody Differentiation
  • HIV-1 Antibody by Multispot
  • Human Immunodeficiency Virus 1/2 (HIV-1/2) Antibody, Differentiation
Human Immunodeficiency Virus Types 1 and 2 (HIV-1/2) Antibody Differentiation, Supplemental