Differential diagnosis of myositis in patients with or without statin exposure.
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Serum Separator Tube (SST).
Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)
Refrigerated. Also acceptable: Frozen.
Other body fluids. Contaminated, hemolyzed, grossly icteric, or severely lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
0-19 Units: Negative
IgG antibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are mainly associated with necrotizing autoimmune myopathy (NAM) in a subset of statin-treated patients. Although infrequent, these antibodies may also be observed in statin-naive patients with NAM. Strong clinical correlation is recommended in the absence of muscle fiber necrosis, elevated serum creatine kinase, perimysial pathology, and/or statin exposure.
Analyte Specific Reagent (ASR)
|Component Test Code*||Component Chart Name||LOINC|
|2013102||HMGCR Antibody, IgG||93493-5|