Ordering Recommendation

Monitor patient adherence.

Mnemonic
BUPRSP
Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Tue, Fri

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Gray (sodium fluoride/potassium oxalate). Also acceptable: Plain red, green (sodium heparin), lavender (EDTA), or pink (K2EDTA).

Specimen Preparation

Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Separator tubes. Plasma or whole blood collected in lt. blue (sodium citrate). Specimens exposed to repeated freeze/thaw cycles. Hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years

Reference Interval

Effective February 16, 2016

Drugs Covered Cutoff Concentrations
Buprenorphine 1 ng/mL
Norbuprenorphine 1 ng/mL

Interpretive Data

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Positive cutoff: 1 ng/mL

For medical purposes only; not valid for forensic use.

The presence of metabolite(s) without parent drug may indicate use of parent drug during the prior week. The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

80348 (Alt code: G0480)

Components
Component Test Code* Component Chart Name LOINC
2002743 Norbuprenorphine, S/P, Quant 53881-9
2002745 Buprenorphine, S/P, Quant 3413-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Belbuca
  • Buprenex
  • Buprenorphine and Metabolite, Serum (Buprenorphine & Metabolites - Confirmation/Quantitation - Serum
  • Butrans
  • Narcan
  • Norbuprenorphine Glucuronide (Buprenorphine & Metabolites - Confirmation/Quantitation - Serum/Plasma
  • Probuphine
  • Sublocade
  • Suboxone
  • Subutex
  • Temgesic
  • Transtec
  • Vetergesic
  • Zubsolv
Buprenorphine and Metabolites, Serum or Plasma, Quantitative