Ordering Recommendation

The intended use of this test is pre-transplant allele matching. Do not use for HLA-related disease screening or diagnosis (eg, celiac disease, narcolepsy, rheumatologic diseases).

Mnemonic

HLA DRB1

Methodology

Polymerase Chain Reaction/Massively Parallel Sequencing

Performed

Varies

Reported

10-13 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA). Also acceptable: yellow (ACD Solution A).

Specimen Preparation

Transport 4 mL whole blood in original container. (Min: 1 mL)
Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Yellow (ACD Solution B) specimens. Clotted, grossly hemolyzed, or heparinized specimens.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By Report

Interpretive Data



Compliance Category

Performed by non-ARUP Laboratory

Note

Hotline History

N/A

CPT Codes

81382

Components

Component Test Code* Component Chart Name LOINC
2012495 HLA-DRB1*, Class II - Locus, Allele 1 19146-0
2012496 HLA-DRB1*, Class II - Locus, Allele 2 19146-0
2012497 HLA-DRB1 by NGS, Interpretation 19146-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

HLA-DRB1 by Next Generation Sequencing

Children’s Hospital of Philadelphia