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Keratan Sulfate, Quantitative by LC-MS/MS, Urine
2012259
Ordering Recommendation

Screening and monitoring of patients with suspected Morquio syndrome (MPS IV), in conjunction with other mucopolysaccharides screen tests.

Mnemonic
KS U MS
Methodology
Quantitative Liquid Chromatography/Tandem Mass Spectrometry
Performed
Varies
Reported
3-10 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Morning void is preferred. 
Collect
Urine. 
Specimen Preparation
Transfer 2 mL urine to ARUP Standard Transport Tube and freeze immediately. (Min: 1 mL) 
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted with multiple tests are ordered. 
Unacceptable Conditions
Specimens containing preservatives. 
Remarks
 
Stability
Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month 
Reference Interval
AgeTotal Keratan Sulfate (ug/mg CRT)
0-11 months5.65 - 20.73
1 year - 5 years1.75 - 6.81
6 years - 15 years0.67 - 4.16
16 years and older0.29 - 0.85

Interpretive Data
Refer to report.
Keratan Sulfate, Total is calculated as the sum of the two disaccharides, LacNAc1 and LacNAc2, per milligram of creatinine (CRT).

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
N/A
CPT Code(s)
83864
Components
Component Test Code*Component Chart NameLOINC
2012260Creatinine, Urine2161-8
2012261LacNAc1 (S1 monosulfated), Urine
2012262LacNAc2 (S2 disulfated), Urine
2012263Keratan Sulfate, Total Urine
2012264Keratan Sulfate, Urine Interpretation
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • MPS IVa