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Keratan Sulfate, Quantitative by LC-MS/MS, Urine
2012259
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Ordering Recommendation
Screening and monitoring of patients with suspected Morquio syndrome (MPS IV), in conjunction with other mucopolysaccharides screen tests.
Mnemonic
KS U MS
Methodology
Quantitative Liquid Chromatography/Tandem Mass Spectrometry
Performed
Varies
Reported
3-10 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Morning void is preferred.
Collect
Urine.
Specimen Preparation
Transfer 2 mL urine to ARUP Standard Transport Tube and freeze immediately. (Min: 1 mL)
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted with multiple tests are ordered.
Unacceptable Conditions
Specimens containing preservatives.
Remarks
Stability
Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month
Reference Interval
| Age | Total Keratan Sulfate (ug/mg CRT) |
| 0-11 months | 5.65 - 20.73 |
| 1 year - 5 years | 1.75 - 6.81 |
| 6 years - 15 years | 0.67 - 4.16 |
| 16 years and older | 0.29 - 0.85 |
Interpretive Data
Refer to report.
Keratan Sulfate, Total is calculated as the sum of the two disaccharides, LacNAc1 and LacNAc2, per milligram of creatinine (CRT).
Compliance Category
Laboratory Developed Test (LDT)
Note
Hotline History
N/A
CPT Codes
83864
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2012260 | Creatinine, Urine | 2161-8 |
| 2012261 | LacNAc1 (S1 monosulfated), Urine | |
| 2012262 | LacNAc2 (S2 disulfated), Urine | |
| 2012263 | Keratan Sulfate, Total Urine | |
| 2012264 | Keratan Sulfate, Urine Interpretation |
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
- MPS IVa
Keratan Sulfate, Quantitative by LC-MS/MS, Urine
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