Screening and monitoring of patients with suspected Morquio syndrome (MPS IV), in conjunction with other mucopolysaccharides screen tests.
Quantitative Liquid Chromatography/Tandem Mass Spectrometry
Morning void is preferred.
Transfer 2 mL urine to ARUP Standard Transport Tube and freeze immediately. (Min: 1 mL)
CRITICAL FROZEN. Separate specimens must be submitted with multiple tests are ordered.
Specimens containing preservatives.
Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month
|Age||Total Keratan Sulfate (ug/mg CRT)|
|0-11 months||5.65 - 20.73|
|1 year - 5 years||1.75 - 6.81|
|6 years - 15 years||0.67 - 4.16|
|16 years and older||0.29 - 0.85|
Refer to report.
Keratan Sulfate, Total is calculated as the sum of the two disaccharides, LacNAc1 and LacNAc2, per milligram of creatinine (CRT).
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|2012261||LacNAc1 (S1 monosulfated), Urine|
|2012262||LacNAc2 (S2 disulfated), Urine|
|2012263||Keratan Sulfate, Total Urine|
|2012264||Keratan Sulfate, Urine Interpretation|
- MPS IVa