Ordering Recommendation
Mnemonic
Methodology
Quantitative ImmunoCAP Fluorescent Enzyme Immunoassay
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
Specimen Required
Multiple patient encounters should be avoided.
Serum separator tube. Multiple specimen tubes should be avoided.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum plus 0.1 mL for each additional allergen ordered to an ARUP Standard Transport Tube. (Min: 0.5 mL plus 0.04 mL for each allergen ordered)
Refrigerated.
Hemolyzed, icteric, or lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval
Reporting Range (reported in kU/L) |
Probability of IgE Mediated Clinical Reaction |
Class Scoring |
---|---|---|
Less than 0.10 | No significant level detected | 0 |
0.10 - 0.34 | Clinical relevance undetermined | 0/1 |
0.35 - 0.70 | Low | 1 |
0.71 - 3.50 | Moderate | 2 |
3.51 - 17.50 | High | 3 |
17.51 - 50.00 | Very high | 4 |
50.01 - 100.00 | Very high | 5 |
Greater than 100.00 | Very high | 6 |
Interpretive Data
Allergen results of 0.10-0.34 kU/L are intended for specialist use as the clinical relevance is undetermined. Even though increasing ranges are reflective of increasing concentrations of allergen-specific IgE, these concentrations may not correlate with the degree of clinical response or skin testing results when challenged with a specific allergen. The correlation of allergy laboratory results with clinical history and in vivo reactivity to specific allergens is essential. A negative test may not rule out clinical allergy or even anaphylaxis.
Alpha-lactoalbumin (Bos d 4) and Beta-lactoglobulin (Bos d 5) are heat labile and associated with a risk for reaction to fresh milk. Casein (Bos d 8) is heat stable and associated with a risk for reaction to all forms of milk. Note: Allergens included in this panel: Alpha-lactoalbumin (Bos d 4), Beta-lactoglobulin (Bos d 5), Casein (Bos d 8) and Milk (Cow's).
FDA
Note
Hotline History
Hotline History
CPT Codes
86003; 86008 x3
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0055020 | Allergen, Food, Milk (Cow) IgE | 7258-7 |
0055074 | Allergen, Food, Beta-lactoglobulin IgE | 41397-1 |
0055081 | Allergen, Food, Casein IgE | 6062-4 |
0099543 | Allergen, Food, Alpha-Lactalbumin IgE | 7445-0 |
Aliases
- ImmunoCap (f76, f77, f78, f2) Milk Allergen Components
- Milk Component Panel
- Milk Components