Ordering Recommendation

Determine etiology of unexplained hemolytic anemia or family history of unexplained hemolytic anemia and in neonates with unexplained hyperbilirubinemia.

Mnemonic
HHA SEQ
Methodology

Massively Parallel Sequencing

Performed

Varies

Reported

3-6 weeks

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Lavender (EDTA) or yellow (ACD Solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report. 

Compliance Category

Laboratory Developed Test (LDT)

Note

Recent CBC result is required. 

GENES TESTED: AK1, ALDOA, ANK1, CDAN1, CYB5R3, EPB41, EPB42, G6PD, GCLC, GPI, GSR, GSS, HK1, NT5C3A, PFKM, PGK1, PIEZO1, PKLR, SEC23B, SLC4A1, SLCO1B1, SLCO1B3, SPTA1, SPTB, TPI1, UGT1A1, UGT1A6, UGT1A7

Hotline History
N/A
CPT Codes

81443

Components
Component Test Code* Component Chart Name LOINC
2012053 Her. Hemolytic Anemia Seq. Specimen 31208-2
2012054 Her. Hemolytic Anemia Sequencing Interp 35474-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Dehydrated hereditary stomatocytosis
  • Gilbert syndrome
  • Glucose-6-phosphate dehydrogenase deficiency
  • Hereditary elliptocytosis
  • Hereditary pyropoikilocytosis
  • Hereditary spherocytosis
  • Pyruvate kinase deficiency
  • RBC enzymopathies
  • RBC membrane defects
  • Xerocytosis
Hereditary Hemolytic Anemia Panel Sequencing