Ordering Recommendation

Aids in diagnosis of acute myelocytic leukemia or other leukemias, sarcoidosis, and infections such as tuberculosis.

Mnemonic
LYSO SER
Methodology

Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun, Tue, Thu

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube (SST).

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed, lipemic, icteric, or contaminated specimens.

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 5 days; Frozen: 1 month.

Reference Interval

Less than or equal to 2.75 µg/mL

Interpretive Data



Compliance Category

FDA

Note

Serum lysozyme levels may be elevated in acute myelomonocytic leukemia (FAB-M4), chronic myelomonocytic leukemia (CMML), and chronic myelocytic leukemia (CML). Increased serum lysozyme activity is present in tuberculosis, sarcoidosis, megaloblastic anemias, acute bacterial infections, ulcerative colitis, regional enteritis, and Crohn disease. Elevated serum lysozyme occurs during severe renal insufficiency, renal transplant rejection, urinary tract infections, pyelonephritis, glomerulonephritis, and nephrosis.

Hotline History
N/A
CPT Codes

85549

Components
Component Test Code* Component Chart Name LOINC
2012040 Lysozyme, Serum 2589-0
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Aliases
  • Muramidase serum
  • Serum lysozyme
Lysozyme, Serum