Ordering Recommendation

Recommended test to confirm a diagnosis of a hereditary cancer syndrome in individuals with personal or family history consistent with features of more than one cancer syndrome. When a relative has a previously identified pathogenic sequence variant, see Familial Mutation, Targeted Sequencing (2001961).

Mnemonic
CANCERPAN
Methodology

Massively Parallel Sequencing/Exonic Oligonucleotide-based CGH Microarray

Performed

Varies

Reported

3-6 weeks

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Lavender (EDTA) or yellow (ACD Solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions
Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Laboratory Developed Test (LDT)

Note

GENES TESTED: ALK, APC, ATM, ATR, AXIN2**, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A, CHEK2*, DICER1, EPCAM****, FH, FLCN, MAX, MEN1, MET, MLH1, MRE11, MSH2, MSH3**, MSH6, MUTYH, NBN, NF1**, NF2, NTHL1, PALB2, PHOX2B, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, RB1, RECQL***, RET, SDHAF2, SDHB, SDHC*, SDHD*, SMAD4, SMARCA4**, SMARCB1, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, WT1**
 
* One or more exons are not covered by sequencing for the indicated gene; see Additional Technical Information.
** Deletion/duplication detection is not available for this gene.
*** One or more exons are not covered by sequencing, and deletion/duplication detection is not available for this gene; see Additional Technical Information.
**** Deletion/duplication only; sequencing is not available for this gene.

Hotline History
N/A
CPT Codes

81432; 81433; 81435; 81436; 81437; 81438

Components
Component Test Code* Component Chart Name LOINC
2012033 Cancer Panel, Hereditary, Spcm 31208-2
2012034 Cancer Panel, Hereditary, Interp 35474-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Birt-Hogg-Dube (BHD) syndrome
  • Cowden syndrome
  • Familial Adenomatous Polyposis (FAP)
  • HBOC syndrome
  • Hereditary Diffuse Gastric Cancer (HDGC)
  • Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) syndrome
  • Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
  • Hereditary Papillary Renal Carcinoma (HPRC) syndrome
  • Hereditary Paraganglioma Pheochromocytoma
  • Juvenile Polyposis syndrome (JPS)
  • Li-Fraumeni syndrome (LFS)
  • Lynch syndrome
  • Malignant Mesothelioma
  • MUTYH-Associated Polyposis (MAP)
  • Peutz-Jegher syndrome (PJS)
  • PTEN Hamartoma Tumor syndrome
  • Rhabdoid Tumor Predisposition syndrome
  • Tuberous Sclerosis Complex (TSC)
  • Von Hippel Lindau (VHL) syndrome
  • Wilms Tumor
Hereditary Cancer Panel, Sequencing and Deletion/Duplication