Ordering Recommendation

Therapeutic monitoring in patients receiving sodium nitroprusside therapy. Screen for thiocyanate poisoning.

Mnemonic
THIO SP
Methodology

Quantitative Colorimetry

Performed

Sun, Thu

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Plain Red, Lavender (K2EDTA), Lavender (K3EDTA), or Pink (K2EDTA).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Whole blood. Gel Separator Tubes, Light Blue (Sodium Citrate), or Yellow (SPS or ACD Solution).

Remarks
Stability

Ambient: 5 days; Refrigerated: 5 days; Frozen: 5 days

Reference Interval

Effective May 15, 2017
Nonsmoker: Less than or equal to 4 µg/mL
Smoker:  3-12 µg/mL
Toxic:  Greater than 50 µg/mL
Values seen with nitroprusside therapy:  6-29 µg/mL

Interpretive Data

The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration.

No compliance statements are in use for this test.

Note

N/A

Hotline History
N/A
CPT Codes

84430

Components
Component Test Code* Component Chart Name LOINC
2011580 Thiocyanate, Ser/Pla
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Nipride, Metabolite of
  • Nitropress Administration
  • Nitroprusside Metabolite
  • Rhodanide
  • Sodium Nitroprusside
Thiocyanate, Serum or Plasma