Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
MEXILE
Methodology

Quantitative Liquid Chromatography/Tandem Mass Spectrometry

Performed

Mon, Thu, Sat

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum Pre-dose (Trough) Draw - At a Steady State Concentration or Plasma Pre-dose (Trough) Draw - At a Steady State Concentration in Plain Red, Lavender (K2EDTA), Lavender (K3EDTA), or Pink (K2EDTA).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Whole blood. Gel Separator Tubes, Light Blue (Sodium Citrate), or Yellow (SPS or ACD Solution).

Remarks
Stability

Ambient: 48 hours; Refrigerated: 5 days; Frozen: 2 months

Reference Interval

Effective November 12, 2018

Therapeutic Range 0.5-2.0 µg/mL
Toxic Level Greater than 2.0 µg/mL

Interpretive Data

The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Toxic concentrations may cause hypotension, tremor and cardiac abnormalities.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

80299

Components
Component Test Code* Component Chart Name LOINC
2011544 Mexiletine, Ser/Pla 3819-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Mexitil
  • Mexitil blood level
Mexiletine, Serum or Plasma