Ordering Recommendation

Useful in the assessment of overload.

Mnemonic
U COP RAND
Methodology

Quantitative Inductively Coupled Plasma-Mass Spectrometry

Performed

Sun-Sat

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician). Collection from patients receiving iodinated or gadolinium-based contrast media must be avoided for a minimum of 72 hours post-exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post contrast media exposure.

Collect

Random urine.

Specimen Preparation

Transfer an 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes (ARUP supply #43116), available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Room temperature or frozen.

Unacceptable Conditions

Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media. Acid preserved urine. Specimens transported in containers other than specified. Specimens contaminated with blood or fecal material.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

Effective November 13,2017

Components
Reference Interval
Copper, Urine 0.3-3.2 µg/dL
Copper Urine - ratio to CRT 10.0-45.0 µg/gCRT

Interpretive Data

Individuals with symptomatic Wilson disease usually excrete more than 100 g copper per day. Other conditions associated with elevated urine copper include cholestatic liver disease, proteinuria, some medications, and contaminated specimens.
Although random specimens may contain diagnostic information, 24-hour collection is a more consistent indicator of elevated copper.

Compliance Category

Laboratory Developed Test (LDT)

Note

Refer to Copper-Ceruloplasmin Index (Copper Free) (ARUP test code 0025079) for Wilson disease screening test. High concentrations of iodine or gadolinium may interfere with elemental testing.

Hotline History
N/A
CPT Codes

82525

Components
Component Test Code* Component Chart Name LOINC
0020100 Copper, Urine - per volume 5632-5
0020207 Creatinine, Urine - per volume 2161-8
0025064 Copper, Urine - ratio to CRT 13829-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 24-hour urine copper
  • Copper/Creatinine Ratio, Urine
  • Cu
  • CUU
  • Normalized Urine Copper
  • Normalized Urine Cu
Copper, Random Urine