2011480
print

  Copper, Random Urine

U COP RAND
Example Reports
High
Normal

Icon

Specimen Collection and Handling

Ordering Recommendation

Useful in the assessment of overload.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and nonessential over-the-counter medications (upon the advice of their physician). Collection from patients receiving iodinated or gadolinium-based contrast media must be avoided for a minimum of 72 hours post exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post contrast media exposure.

Collect

Random urine.

Specimen Preparation

Transfer an 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes (ARUP supply #43116), available online through eSupply using ARUP Connect(TM) or contact ARUP Client Services at 800-522-2787. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Room temperature or frozen.

Unacceptable Conditions

Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media. Acid preserved urine. Specimens transported in containers other than specified. Specimens contaminated with blood or fecal material.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 1 year

Methodology

Quantitative Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Performed

Sun-Sat

Reported

1-5 days

Reference Interval

  Effective February 16, 2021

Test Number
 Components
 Reference Interval
  Copper, Urine - ratio to CRT 10.0-45.0 microg/g CRT
  Copper, Urine - per volume Less than or equal to 3.2 microg/dL

Interpretive Data

  Individuals with symptomatic Wilson disease usually excrete more than 100 ug copper per day. Other conditions associated with elevated urine copper include cholestatic liver disease, proteinuria, and some medications., and contaminated specimens.
Although random specimens may contain diagnostic information, a 24-hour collection is a more consistent indicator of urine copper.
Elevated results may be due to skin or collection-related contamination, including the use of collection containers that are not certified to be trace element-free. If an elevated result is suspected to be due to contamination, confirmation with a second specimen collected in a certified trace element-free container is recommended.
Methodology: Inductively Coupled Plasma - Mass Spectrometry (ICP-MS)

Compliance Category

Laboratory Developed Test (LDT)

Note

  High concentrations of iodine or gadolinium may interfere with elemental testing.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
01/20/2026
X
N/A

CPT Codes

82525

Are you an ARUP Client? Click here for your pricing.

Components

Component Test Code* Component Chart Name LOINC
0020100 Copper, Urine - per volume 30920-3
0020207 Creatinine, Urine - per volume 35674-1
0025064 Copper, Urine - ratio to CRT 13829-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 24-hour urine copper
  • Copper/Creatinine Ratio, Urine
  • Cu
  • CUU
  • Normalized Urine Copper
  • Normalized U
Copper, Random Urine