Copper, Random Urine

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Specimen Collection and Handling

Ordering Recommendation

Useful in the assessment of overload.

Mnemonic

U COP RAND

Methodology

Quantitative Inductively Coupled Plasma-Mass Spectrometry

Performed

Sun-Sat

Reported

1-5 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician). Collection from patients receiving iodinated or gadolinium-based contrast media must be avoided for a minimum of 72 hours post-exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post contrast media exposure.

Collect

Random urine.

Specimen Preparation

Transfer an 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes (ARUP supply #43116), available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Room temperature or frozen.

Unacceptable Conditions

Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media. Acid preserved urine. Specimens transported in containers other than specified. Specimens contaminated with blood or fecal material.

Remarks
Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

Effective February 16, 2021

Components
 Reference Interval
Copper, Urine Less than or equal to 3.2 µg/dL
Copper Urine - ratio to CRT 10.0-45.0 µg/gCRT

Interpretive Data

Individuals with symptomatic Wilson disease usually excrete more than 100 g copper per day. Other conditions associated with elevated urine copper include cholestatic liver disease, proteinuria, some medications, and contaminated specimens.
Although random specimens may contain diagnostic information, 24-hour collection is a more consistent indicator of elevated copper.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Refer to Copper-Ceruloplasmin Index (Copper Free) (ARUP test code 0025079) for Wilson disease screening test. High concentrations of iodine or gadolinium may interfere with elemental testing.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/16/2021
X
N/A

CPT Codes

82525

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Components

Component Test Code* Component Chart Name LOINC
0020100 Copper, Urine - per volume 5632-5
0020207 Creatinine, Urine - per volume 2161-8
0025064 Copper, Urine - ratio to CRT 13829-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 24-hour urine copper
  • Copper/Creatinine Ratio, Urine
  • Cu
  • CUU
  • Normalized Urine Copper
  • Normalized Urine Cu
Copper, Random Urine