Useful in the assessment of overload.
Quantitative Inductively Coupled Plasma-Mass Spectrometry
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician). Collection from patients receiving iodinated or gadolinium-based contrast media must be avoided for a minimum of 72 hours post-exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post contrast media exposure.
Transfer an 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes (ARUP supply #43116), available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL)
Refrigerated. Also acceptable: Room temperature or frozen.
Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media. Acid preserved urine. Specimens transported in containers other than specified. Specimens contaminated with blood or fecal material.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 1 year
Effective February 16, 2021
|Copper, Urine||Less than or equal to 3.2 µg/dL|
|Copper Urine - ratio to CRT||10.0-45.0 µg/gCRT|
Individuals with symptomatic Wilson disease usually excrete more than 100 g copper per day. Other conditions associated with elevated urine copper include cholestatic liver disease, proteinuria, some medications, and contaminated specimens.
Although random specimens may contain diagnostic information, 24-hour collection is a more consistent indicator of elevated copper.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Refer to Copper-Ceruloplasmin Index (Copper Free) (ARUP test code 0025079) for Wilson disease screening test. High concentrations of iodine or gadolinium may interfere with elemental testing.
|Component Test Code*||Component Chart Name||LOINC|
|0020100||Copper, Urine - per volume||5632-5|
|0020207||Creatinine, Urine - per volume||2161-8|
|0025064||Copper, Urine - ratio to CRT||13829-7|
- 24-hour urine copper
- Copper/Creatinine Ratio, Urine
- Normalized Urine Copper
- Normalized Urine Cu