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Aminolevulinic Acid (ALA), Random Urine
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Ordering Recommendation
Evaluate suspected aminolevulinic acid dehydratase deficiency (ADP) porphyria or hereditary tyrosinemia.
Mnemonic
Methodology
Quantitative Ion Exchange Chromatography/Spectrophotometry
Performed
Mon, Wed, Fri
Reported
1-4 days
New York DOH Approval Status
Specimen Required
Refrain from alcohol consumption 24 hours prior to collection.
Random urine.
Transfer a 4 mL aliquot from a well-mixed collection to an ARUP Standard Transport Tube. (Min: 1.2 mL)
Refrigerated.
Body fluids other than urine.
Ambient: Unacceptable; Refrigerated: 4 days; Frozen: 1 month
Reference Interval
| Components |
Reference Interval |
|---|---|
| Aminolevulinic Acid - per volume | 0-35 µmol/L |
| ALA, Random Urine - ratio to CRT | By Report |
Interpretive Data
Standard
Note
Increased ALA concentration is associated with exposure to alcohol, lead, and a variety of other agents. Massive elevation of ALA occurs in the acute porphyrias and hereditary tyrosinemia.
Specimen preservation with acid or base may interfere with results. If collected urine will be used for additional testing, remove the ALA aliquot before adding any acid or base preservatives.
Hotline History
CPT Codes
82135
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0020207 | Creatinine, Urine - per volume | 2161-8 |
| 0080104 | Aminolevulinic Acid - per volume | 34284-0 |
| 2011475 | ALA, Random Urine ratio to CRT | 39782-8 |
Aliases
- 5-Aminolevulinic Acid
- ALA
- Delta-ALA
- Delta-Aminolevulinic Acid
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