Myeloid Malignancies Mutation Panel by Next Generation Sequencing

2011117
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Additional Technical Information
Ordering Recommendation

Use to assess for single gene mutations, including substitutions and smaller insertions and deletions that may have prognostic and/or therapeutic significance in AML, myelodysplastic syndromes, myeloproliferative neoplasms, or MDS/MPN overlap disorders such as chronic myelomonocytic leukemia.

Mnemonic
MYE NGS
Methodology

Massively Parallel Sequencing

Performed

Varies

Reported

12-14 days

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Lavender (EDTA), Green (sodium heparin), Bone Marrow (EDTA), or Bone Marrow (sodium heparin). Fresh-frozen tissue.

Specimen Preparation

Whole Blood and Bone Marrow: Transport 3 mL. (Min: 1.5 mL)
Fresh-frozen Tissue: Transport 5 mg fresh-frozen tissue. (Min: 5 mg)
Separate specimens must be submitted when multiple tests are ordered

Storage/Transport Temperature

Whole Blood or Bone Marrow: Refrigerated.
Fresh-frozen Tissue: Frozen.

Unacceptable Conditions

Serum, plasma, grossly hemolyzed specimens, buccal brush or swab, FFPE tissue.

Remarks
Stability

Whole Blood or Bone Marrow: Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable
Fresh-frozen Tissue: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Genes tested: ANKRD26, ASXL1, ASXL2, BCOR, BCORL1, BRAF, CALR, CBL, CBLB, CEBPA, CSF3R, CUX1*, DDX41, DNMT1*, DNMT3A, ELANE, ETNK1, ETV6, EZH2, FBXW7, FLT3, GATA1, GATA2, GNAS, HNRNPK, IDH1, IDH2, IL7R, JAK1, JAK2, JAK3, KDM6A*, KIT, KMT2A, KRAS, LUC7L2, MPL, NOTCH1, NPM1*, NRAS, NSD1, PHF6, PIGA, PRPF40B, PRPF8, PTPN11, RAD21, RUNX1, SETBP1, SF3B1, SH2B3, SMC1A, SMC3, SRSF2, STAG2, STAT3, STAT5B*, SUZ12*, TET2, TP53, U2AF1, U2AF2, WT1, ZRSR2

*One or more exons are not covered by sequencing for the indicated gene; see Additional Technical Information

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
11/16/2020
X
X
05/20/2019
X
N/A
CPT Codes

81455

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Components
Component Test Code* Component Chart Name LOINC
2011118 Myeloid Malignancy Proposed Diagnosis
2011119 Myeloid Malignancies Panel Specimen 31208-2
2011120 Myeloid Malignancies Panel Interp 35474-6
2011121 EER Myeloid Malignancies Panel by NGS 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Acute myeloid leukemia, AML
  • Atypical chronic myelogenous leukemia, aCML
  • Chronic eosinophilic leukemia not otherwise specified
  • Chronic myelogenous leukemia, BCR-ABL1 positive, CML
  • Chronic myelomonocytic leukemia, CMML
  • Chronic neutrophilic leukemia, CNL
  • Eosinophilia
  • Juvenile myelomonocytic leukemia, JMML
  • Mastocytosis
  • Myelodysplastic syndrome with isolated del(5q)
  • Myelodysplastic syndromes, MDS
  • Myelodysplastic/Myeloproliferative neoplasm
  • Myeloproliferative neoplasm, essential thrombocythemia, MPN-ET
  • Myeloproliferative neoplasm, MDS/MPN
  • Myeloproliferative neoplasm, polycythemia vera, MPN-PV
  • Myeloproliferative neoplasm, primary myelofibrosis, MPN-PMF
  • Refractory anemia with excess blasts, RAEB
  • Refractory anemia with ring sideroblasts associated with marked thrombocytosis, RARS-T
  • Refractory anemia with ring sideroblasts, RARS
  • Refractory cytopenia with multilineage dysplasia, RCMD
  • Refractory cytopenia with unilineage dsysplasia, RCUD
Myeloid Malignancies Mutation Panel by Next Generation Sequencing