2011034
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N-Methylhistamine, 24-Hour Urine

NMETHYL U
Example Reports
Abnormal
Normal

Ordering Recommendation

Aids in the evaluation of patients with allergic signs and symptoms, such as anaphylaxis. May assist in diagnosing and monitoring mast cell activation disorders or in evaluating histamine production over a longer time frame. A 24-hour urine collection of 300 mL or greater is required. If submitting a random urine or 24-hour collection with a total volume of less than 300 mL, refer to N-Methylhistamine, Random Urine (3002743).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Patient must not be taking monoamine oxidase inhibitors (MAOIs) or aminoguanidine as these medications increase N-methylhistamine (NMH) levels.

Collect

24-hour urine.

Specimen Preparation

From a well-mixed 24-hour collection transfer 5 mL urine to ARUP standard transport tubes. (Min: 3 mL)
Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.

Storage/Transport Temperature

Refrigerated. Also acceptable: Room temperature or frozen.

Unacceptable Conditions
Remarks

Collection duration and urine volume must be provided for testing. Total collection volume must be greater than 300 mL.

Stability

Ambient: 2 weeks; Refrigerated: 28 days; Frozen: 28 days

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry/Colorimetry

Performed

Varies

Reported

6-12 days

Reference Interval

By Report

Interpretive Data



Compliance Category

Performed by non-ARUP Laboratory

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
12/02/2024
X
X
N/A

CPT Codes

82542

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Components

Component Test Code* Component Chart Name LOINC
2011035 Collection Duration (h) 13362-9
2011036 Urine Volume (mL) 3167-4
2011037 N-Methylhistamine, 24 Hr Urine 44340-8
2011038 Creatinine Concentration, 24 Hr Urine 20624-3
3002790 Creatinine, 24 Hr Urine 2162-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 1-Methylhistamine
  • Histamine Metabolites
  • Urinary N-Methylhistamine
N-Methylhistamine, 24-Hour Urine

Mayo Clinic Laboratories