2010921
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Eosinophil Granule Major Basic Protein, Tissue Biopsy

EGMBP TIS
Example Reports
Enhanced Report
Negative
Positive

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Clinical Information for Immunodermatology (Tissue Testing)

Ordering Recommendation

Use to identify eosinophil activity and involvement in tissues or organs with suspected eosinophil-related pathophysiology. This test uses indirect immunofluorescence to detect cellular localization and extracellular deposition of the eosinophil granule core protein (major basic protein 1 [eMBP1]), and/or the eosinophil granule matrix protein (eosinophil-derived neurotoxin [EDN]). 

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Tissue.

Specimen Preparation

Transport tissue (optimal 3-8 mm) in Michel medium (ARUP supply #45462) available online through eSupply using ARUP Connect ™ or call ARUP Client Services at 800- 522-2787. (Min: 1 mm).
Also acceptable: Zeus tissue fixative, flash frozen fresh tissue, formalin fixed tissue, or formalin-fixed and paraffin-embedded tissue. Transport in formalin, tissue block, or slides with two 4-5-micron sections per slide in serial order and numbered. (Min: 8 slides).

Storage/Transport Temperature

Room temperature.
Flash Frozen Fresh Tissue: Frozen

Unacceptable Conditions
Remarks
Stability

Michel Medium or Zeus Tissue Fixative: Ambient: 10 days; Refrigerated: 10 days; Frozen: Unacceptable
Formalin-Fixed Tissue: Ambient: 3 weeks; Refrigerated: 3 weeks; Frozen: Unacceptable
Flash Frozen Fresh Tissue: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: Indefinitely
Paraffin-Embedded Tissue: Ambient:  Indefinitely; Refrigerated:  Indefinitely; Frozen: Indefinitely

Methodology

Indirect Immunofluorescence (IIF)

Performed

Varies

Reported

7-21 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory

Note

Turnaround time may be prolonged on specimens submitted in formalin or as formalin-fixed, paraffin-embedded (FFPE) tissue blocks or slide with sections; clients should consider contacting the Immunodermatology Laboratory when submitting FFPE tissue for Eosinophil Granule Major Basic Protein, Tissue to discuss specific clinical information that may indicate expedited testing and resulting. Contact ARUP Client Services at 800-242-2787, option 2, and ask to speak with the Immunodermatology Laboratory at the University of Utah regarding patient results and/or testing information. If formalin-fixed or FFPE tissue is submitted, additional stain will be performed.

If multiple specimens are submitted, testing will be performed on each specimen. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/19/2024
X
X
X
N/A

CPT Codes

88305; 88342; if Formalin Fixed tissue, add 88341

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Components

Component Test Code* Component Chart Name LOINC
0097167 Specimen Medium and Quantity 31208-2
2010911 EER Eosinophil Granule MBP in Tissues 11526-1
2010922 Eosinophil Granule MBP in Tissues 10478-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • eosinophil degranulation
  • eosinophil granule core
  • Eosinophil Granule Major Basic Protein, Biopsy
  • eosinophil granule matrix
  • eosinophil MBP
  • eosinophil-associated disease (EAD)
  • eosinophil-related disease
  • eosinophil-related inflammation
  • eosinophilic
  • eosinophilic inflammation
  • extracellular eMBP1
Eosinophil Granule Major Basic Protein, Tissue Biopsy