Ordering Recommendation

Aid in the diagnosis of paraneoplastic neurologic syndromes associated with malignancy for CSF specimens only.

Mnemonic
PCCAANNA C
Methodology

Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot

Performed

Sun, Wed, Fri

Reported

1-6 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

CSF

Specimen Preparation

Transfer 2 mL CSF to an ARUP Standard Transport Tube. (Min: 0.75 mL)

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions

Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.

Remarks
Stability

Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
Test Number
Components
Reference Interval
  Paraneoplastic Abs (PCCA/ANNA) IgG, CSF None Detected
  Neuronal Nuclear Ab Titer, IgG CSF Less than 1:1
  Purkinje Cell Antibody Titer IgG, CSF Less than 1:1
2010847 Neuronal Nuclear Antibodies (Hu, Ri, Yo) IgG by Immunoblot, CSF Effective August 17, 2020
Test Number
Components
Reference Interval
  Neuronal Nuclear Ab (Hu) IgG, IB, CSF Refer to report
  Neuronal Nuclear Ab (Ri) IgG, IB, CSF Refer to report
  Neuronal Nuclear Ab (Yo) IgG, IB, CSF Refer to report

Interpretive Data



Compliance Category

Laboratory Developed Test (LDT)

Note

PCCA/ANNA antibodies are screened by IFA. If the IFA screen is indeterminate then the Immunoblot will be added. If the IFA screen is positive at 1:1, then a specific titer (PCCA or ANNA) and Immunoblot will be added. Additional charges apply.

Hotline History
N/A
CPT Codes

86255; if reflexed add 84182 x3 and/or 86256

Components
Component Test Code* Component Chart Name LOINC
2010842 Paraneoplastic Abs (PCCA/ANNA) IgG, CSF
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot, CSF