Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot, CSF

2010841
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Example Reports
Detected
None Detected

Ordering Recommendation

Aid in the diagnosis of paraneoplastic neurologic syndromes associated with malignancy for CSF specimens only.

Mnemonic

PCCAANNA C

Methodology

Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot

Performed

Sun, Wed, Fri

Reported

1-6 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

CSF

Specimen Preparation

Transfer 2 mL CSF to an ARUP Standard Transport Tube. (Min: 0.75 mL)

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions

Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.

Remarks
Stability

Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
 Components
 Reference Interval
  Paraneoplastic Abs (PCCA/ANNA) IgG, CSF None Detected
  Neuronal Nuclear Ab Titer, IgG CSF Less than 1:1
  Purkinje Cell Antibody Titer IgG, CSF Less than 1:1
3004527 Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot, CSF
Test Number Components Reference Interval
Neuronal Nuclear Ab (Hu) IgG, IB, CSF Negative
Neuronal Nuclear Ab (Ri) IgG, IB, CSF Negative
Neuronal Nuclear Ab (Yo) IgG, IB, CSF Negative
Neuronal Nuclear Ab (TR/DNER) IgG, CSF Negative

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

PCCA/ANNA antibodies are screened by IFA. If the IFA screen is indeterminate then the Immunoblot will be added. If the IFA screen is positive at 1:1, then a specific titer (PCCA or ANNA) and Immunoblot will be added. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/22/2022
X
X
X
08/17/2020
X
X
N/A

CPT Codes

86255; if reflexed add 84182 x4 and/or 86256

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Components

Component Test Code* Component Chart Name LOINC
2010842 Paraneoplastic Abs (PCCA/ANNA) IgG, CSF 14247-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot, CSF