Ordering Recommendation

Aid in the evaluation of unexplained hypercalcemia, particularly in suspected hypercalcemia of malignancy. Amino (N)- and carboxy (C)-terminus PTHrP fragments, such as those produced by some patients with renal insufficiency, do not interfere with this assay.

Mnemonic

PTHRP

Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun, Mon, Wed, Fri

Reported

2-6 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Protease Inhibitor tube (PPACK; Phe-Pro-Arg-chloromethylketone)  (ARUP supply #49662), available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.  A winged collection set must be used.

Specimen Preparation

Mix well. Separate from cells within 1 hour of collection. Transfer 1.5 mL plasma to an ARUP Standard Transport Tube. (Min: 0.7 mL)

Storage/Transport Temperature

Frozen. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Grossly hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 3 months

Reference Interval

Effective August 17, 2015

Age Male
Female
Under 18 years Not established Not established
18 years and older 0.0-2.3 pmol/L 0.0-3.4 pmol/L

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Amino (N)- and carboxy (C)-terminus PTHrP fragments, such as those produced by some patients with renal insufficiency, do not interfere with this assay.

Hotline History

N/A

CPT Codes

82542

Components

Component Test Code* Component Chart Name LOINC
0093016 PTHrP by LC-MS/MS, Plasma 15087-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • HHM
  • Humoral Hypercalcemia of Malignancy Factor
  • Parathyroid Hormone Related Peptide
  • Parathyroid Hormone Related Protein
  • Parathyroid Related Polypeptide
  • Parathyroid Related Protein
  • PRP
  • PTH Related Peptide
  • PTH Related Protein
  • PTH-RP
  • PTHrP secretion
  • PTHRP, Plasma
Parathyroid Hormone-Related Peptide (PTHrP) by LC-MS/MS, Plasma