Ordering Recommendation

Aid in the evaluation of unexplained hypercalcemia, particularly in suspected hypercalcemia of malignancy. Amino (N)- and carboxy (C)-terminus PTHrP fragments, such as those produced by some patients with renal insufficiency, do not interfere with this assay.

Mnemonic
PTHRP
Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun, Mon, Wed, Fri

Reported

2-6 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Protease Inhibitor tube (PPACK; Phe-Pro-Arg-chloromethylketone)  (ARUP supply #49662), available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.  A winged collection set must be used.

Specimen Preparation

Mix well. Separate from cells within 1 hour of collection. Transfer 1.5 mL plasma to an ARUP Standard Transport Tube. (Min: 0.7 mL)

Storage/Transport Temperature

Frozen. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Grossly hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 3 months

Reference Interval

Effective August 17, 2015

Age Male
Female
Under 18 years Not established Not established
18 years and older 0.0-2.3 pmol/L 0.0-3.4 pmol/L

Interpretive Data



Compliance Category

Laboratory Developed Test (LDT)

Note

Amino (N)- and carboxy (C)-terminus PTHrP fragments, such as those produced by some patients with renal insufficiency, do not interfere with this assay.

Hotline History
N/A
CPT Codes

82542

Components
Component Test Code* Component Chart Name LOINC
0093016 PTHrP by LC-MS/MS, Plasma 15087-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • HHM
  • Humoral Hypercalcemia of Malignancy Factor
  • Parathyroid Hormone Related Peptide
  • Parathyroid Hormone Related Protein
  • Parathyroid Related Polypeptide
  • Parathyroid Related Protein
  • PRP
  • PTH Related Peptide
  • PTH Related Protein
  • PTH-RP
  • PTHrP secretion
  • PTHRP, Plasma
Parathyroid Hormone-Related Peptide (PTHrP) by LC-MS/MS, Plasma