Ordering Recommendation

Aid in the evaluation of unexplained hypercalcemia, particularly in suspected hypercalcemia of malignancy. Amino (N)- and carboxy (C)-terminus PTHrP fragments, such as those produced by some patients with renal insufficiency, do not interfere with this assay.

Mnemonic
PTHRP
Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun, Mon, Wed, Fri

Reported

2-6 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Protease Inhibitor tube (PPACK; Phe-Pro-Arg-chloromethylketone)  (ARUP supply #49662), available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.  A winged collection set must be used.

Specimen Preparation

Mix well. Separate from cells within 1 hour of collection. Transfer 1.5 mL plasma to an ARUP Standard Transport Tube. (Min: 0.7 mL)

Storage/Transport Temperature

Frozen. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Grossly hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 3 months

Reference Interval

Effective August 17, 2015

Age Male
Female
Under 18 years Not established Not established
18 years and older 0.0-2.3 pmol/L 0.0-3.4 pmol/L

Interpretive Data



Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note

Amino (N)- and carboxy (C)-terminus PTHrP fragments, such as those produced by some patients with renal insufficiency, do not interfere with this assay.

Hotline History
N/A
CPT Codes

82542

Components
Component Test Code* Component Chart Name LOINC
0093016 PTHrP by LC-MS/MS, Plasma 15087-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • HHM
  • Humoral Hypercalcemia of Malignancy Factor
  • Parathyroid Hormone Related Peptide
  • Parathyroid Hormone Related Protein
  • Parathyroid Related Polypeptide
  • Parathyroid Related Protein
  • PRP
  • PTH Related Peptide
  • PTH Related Protein
  • PTH-RP
  • PTHrP secretion
  • PTHRP, Plasma
Parathyroid Hormone-Related Peptide (PTHrP) by LC-MS/MS, Plasma