Ordering Recommendation

Use to diagnose H. pylori infection in adults (>17 years of age). For children and adolescents, refer to Helicobacter pylori Breath Test, Pediatric (2010925).

Mnemonic
UBIT
Methodology

Qualitative Spectrophotometry

Performed

Sun-Sat

Reported

Within 4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

This test requires the adult patient (>17 years of age) to fast for 1 hour prior to test administration. The patient should not have taken antibiotics, proton pump inhibitors (e.g., Prilosec, Prevacid, Aciphex, Nexium), or bismuth preparations (e.g., Pepto-Bismol) within the previous 14 days. The effect of histamine 2-receptor antogonists (e.g., Axid, Pepcid, Tagamet, Zantac) may reduce urease activity on urea breath tests and should be discontinued for 24-48 hours before the sample is collected.
When used to monitor treatment, the test should be performed four weeks after cessation of definitive therapy. The patient should be informed that the Pranactin-Citric drink that will be administered contains phenylalanine. Phenylketonurics restrict dietary phenylalanine.

Collect

BreathTek UBT Kit (ARUP Supply #51124 ) available online through eSupply using ARUP Connect™ or contact ARUPClient Services at (800) 522-2787.

Specimen Preparation

1) Label breath collection bags with patient name, MRN, date and time of collection, and indicate Pre (blue) or Post (pink).
2) Collect the baseline (Pre) breath specimen according to the instructions in the BreathTek UBT kit.
3) After the allotted time, collect the Post breath specimen according to the instructions in the kit.

Storage/Transport Temperature

CRITICAL ROOM TEMPERATURE. Do not freeze.

Unacceptable Conditions

Underinflated bags. Pediatric specimens

Remarks

For a valid result, the post breath specimen must be collected between 15 and 30 minutes after the patient drinks the Pranactin-Citric solution.

Stability

Ambient: 1 week; Refrigerated: Unacceptable; Frozen: Unacceptable

Reference Interval

Negative

Interpretive Data

A negative result does not rule out the possibility of H. pylori infection. If clinical signs are suggestive of H. pylori infection, retest with a new specimen or an alternate method. Known causes of false negative results include:
1.  Use of antibiotics, proton pump inhibitors, and bismuth preparations during the preceding 2 weeks.
2.  Administration of the breath test less than 4 weeks after completion of definitive therapy to eradicate H. pylori.
3.  Premature or late collection of the post-dose specimen.

Known causes of false positive results include:
1. Patients with achlorhydria.
2. Rinsing the testing solution in the mouth or not using the straw provided in the kit, which can allow contact with urease-positive bacteria.
3. The presence of other gastric spiral organisms such as Helicobacter heilmanii.

No compliance statements are in use for this test.

Note

The post-dose sample must be collected between 15 and 30 minutes post-dose to prevent a false negative result.

Hotline History
N/A
Components
Component Test Code* Component Chart Name LOINC
0020646 H. pylori Breath Test 29891-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 13C Urea Breath Test
  • H. Pylori Urea Breath Test
  • Helicobactor Breath Test
  • Pylori
  • Ulcer Breath Test
  • Urea Breath Test
Helicobacter pylori Breath Test, Adult