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Benzodiazepines, Serum or Plasma, Quantitative
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Optimize drug therapy and monitor patient adherence.
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Tue, Fri
1-5 days
Gray (sodium fluoride/potassium oxalate). Also acceptable: Plain red, green (sodium heparin), lavender (EDTA), or pink (K2EDTA).
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1 mL)
Refrigerated.
Gel separator tubes. Plasma or whole blood collected in lt. blue (sodium citrate). Hemolyzed specimens.
After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years (Avoid repeated freeze/thaw cycles)
Effective November 16, 2015
| Drugs Covered | Cutoff Concentrations |
| Alprazolam | 5 ng/mL |
| Alpha-hydroxyalprazolam | 5 ng/mL |
| Clonazepam | 5 ng/mL |
| Chlordiazepoxide | 20 ng/mL |
| 7-aminoclonazepam | 5 ng/mL |
| Diazepam | 5 ng/mL |
| Lorazepam | 20 ng/mL |
| Alpha-hydroxymidazolam | 20 ng/mL |
| Midazolam | 20 ng/mL |
| Nordiazepam | 20 ng/mL |
| Oxazepam | 20 ng/mL |
| Temazepam | 20 ng/mL |
Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry.
Positive cutoff: 20 ng/mL unless specified below:
Diazepam 5 ng/mL
Alprazolam 5 ng/mL
Alpha-hydroxyalprazolam 5 ng/mL
Clonazepam 5 ng/mL
7-aminoclonazepam 5 ng/mL
For medical purposes only; not valid for forensic use.
Identification of specific drug(s) taken by specimen donor is problematic due to common metabolites, some of which are prescription drugs themselves. The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.
Laboratory Developed Test (LDT)
80346 (Alt code: G0480)
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2010447 | Diazepam, S/P, Quant | 3548-5 |
| 2010448 | Nordiazepam, S/P, Quant | 3537-8 |
| 2010449 | Oxazepam, S/P, Quant | 59730-2 |
| 2010450 | Temazepam, S/P, Quant | 10343-2 |
| 2010451 | Lorazepam, S/P, Quant | 3724-2 |
| 2010452 | Alprazolam, S/P, Quant | 3312-6 |
| 2010453 | Alpha-hydroxyalprazolam, S/P, Quant | 27921-6 |
| 2010454 | Clonazepam, S/P, Quant | 3494-2 |
| 2010455 | 7-aminoclonazepam, S/P, Quant | 28059-4 |
| 2010459 | Midazolam, S/P, Quant | 3821-6 |
| 2012676 | Chlordiazepoxide, S/P, Quant | 3457-9 |
| 2012677 | Alpha-hydroxymidazolam, S/P, Quant | 69797-9 |
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