Ordering Recommendation
Preferred test for evaluating if etiology of hypoglycemia is sulfonylurea ingestion.
Mnemonic
Methodology
Qualitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun, Tue, Thu
Reported
1-6 days
New York DOH Approval Status
Specimen Required
Plain red, gray (NaF/K Oxalate), green (Na Heparin), lavender (EDTA), or pink (K2EDTA).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.4 mL)
Frozen. Also acceptable: Refrigerated.
Separator tubes.
Ambient: 48 hours; Refrigerated: 11 days; Frozen: 3 months
Reference Interval
Available Separately | Drug | Cutoff Concentration |
---|---|---|
No | Glyburide | 5 ng/mL |
No | Glimepiride | 5 ng/mL |
No | Glipizide | 5 ng/mL |
No | Repaglinide | 5 ng/mL |
No | Nateglinide | 5 ng/mL |
No | Acetohexamide | 100 ng/mL |
No | Chlorpropamide | 100 ng/mL |
No | Tolazamide | 100 ng/mL |
No | Tolbutamide | 100 ng/mL |
Interpretive Data
This assay is used to evaluate hypoglycemia that may be caused from the ingestion of sulfonylurea drugs. Hypoglycemic drugs are detected (present) in this assay if the drug concentration is greater than the limit of detection (cut-off). The presence of hypoglycemic drug(s) indicates a recent ingestion.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
80377 (Alt code: G0480)
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2010293 | Tolbutamide, Serum/Plasma | 21567-3 |
2010294 | Tolazamide, Serum/Plasma | 21566-5 |
2010295 | Repaglinide, Serum/Plasma | 48328-9 |
2010296 | Nateglinide, Serum/Plasma | 49487-2 |
2010297 | Glyburide, Serum/Plasma | 48327-1 |
2010298 | Glipizide, Serum/Plasma | 48326-3 |
2010299 | Glimepiride, Serum/Plasma | 48325-5 |
2010300 | Chlorpropamide, Serum/Plasma | 48329-7 |
2010301 | Acetohexamide, Serum/Plasma | 43626-1 |
Aliases
- Amaryl (Glimepiride)
- Diabinese (Chlorpropamide)
- Diabinese{R} (Sulfonylurea Hypoglycemics Panel (Qualitative), Serum or Plasma)
- Dymelor (Acetohexamide)
- Glucotrol (Glipizide)
- Meglitinides
- Micronase (Glyburide)
- Orinase (Tolbutamide)
- Prandin (Regaglinide)
- Starlix (Nateglinide)
- Tolinase (Tolazamide)