Ordering Recommendation

Preferred test for evaluating if etiology of hypoglycemia is sulfonylurea ingestion.




Qualitative Liquid Chromatography-Tandem Mass Spectrometry


Sun, Tue, Thu


1-6 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Plain red, gray (NaF/K Oxalate), green (Na Heparin), lavender (EDTA), or pink (K2EDTA).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.4 mL)

Storage/Transport Temperature

Frozen. Also acceptable: Refrigerated.

Unacceptable Conditions

Separator tubes.


Ambient: 48 hours; Refrigerated: 11 days; Frozen: 3 months

Reference Interval

Available Separately Drug Cutoff Concentration
No Glyburide 5 ng/mL
No Glimepiride 5 ng/mL
No Glipizide 5 ng/mL
No Repaglinide 5 ng/mL
No Nateglinide 5 ng/mL
No Acetohexamide 100 ng/mL
No Chlorpropamide 100 ng/mL
No Tolazamide 100 ng/mL
No Tolbutamide 100 ng/mL

Interpretive Data

This assay is used to evaluate hypoglycemia that may be caused from the ingestion of sulfonylurea drugs. Hypoglycemic drugs are detected (present) in this assay if the drug concentration is greater than the limit of detection (cut-off). The presence of hypoglycemic drug(s) indicates a recent ingestion.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes

80377 (Alt code: G0480)


Component Test Code* Component Chart Name LOINC
2010293 Tolbutamide, Serum/Plasma 21567-3
2010294 Tolazamide, Serum/Plasma 21566-5
2010295 Repaglinide, Serum/Plasma 48328-9
2010296 Nateglinide, Serum/Plasma 49487-2
2010297 Glyburide, Serum/Plasma 48327-1
2010298 Glipizide, Serum/Plasma 48326-3
2010299 Glimepiride, Serum/Plasma 48325-5
2010300 Chlorpropamide, Serum/Plasma 48329-7
2010301 Acetohexamide, Serum/Plasma 43626-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Amaryl (Glimepiride)
  • Diabinese (Chlorpropamide)
  • Diabinese{R} (Sulfonylurea Hypoglycemics Panel (Qualitative), Serum or Plasma)
  • Dymelor (Acetohexamide)
  • Glucotrol (Glipizide)
  • Meglitinides
  • Micronase (Glyburide)
  • Orinase (Tolbutamide)
  • Prandin (Regaglinide)
  • Starlix (Nateglinide)
  • Tolinase (Tolazamide)
Hypoglycemia Panel, Sulfonylureas Qualitative, Serum or Plasma