Ordering Recommendation

Preferred test for FFPE tissue at time of diagnosis for detecting prognostically important genomic abnormalities in leukemias/lymphomas and solid tumors involving loss/gain of DNA or loss of heterozygosity (LOH). Monitor disease progression and response to therapy.

Mnemonic
FFPE ARRAY
Methodology

Molecular Inversion Probe Array

Performed

Sun-Sat

Reported

2-3 weeks

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Tumor tissue

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport 10 slides, each with 5-micron unstained sections or four 20-micron scrolls or tissue block. Tissue block will be returned after testing. Transport tissue in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Specimens fixed or processed in alternative fixatives or heavy metal fixatives (B-4 or B-5).

Remarks
Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval
Interpretive Data

For detection of copy number alterations and loss of heterozygosity in FFPE specimens.
Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Samples must contain a region with at least 50 percent tumor.

Hotline History
N/A
CPT Codes

88381; 81277

Components
Component Test Code* Component Chart Name LOINC
2002148 Block ID 57723-9
2010230 Cytogenomic MIP Array, FFPE 62375-1
2010231 EER Cytogenomic MIP Microarray, FFPE 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • aCGH
  • array CGH
  • Array Comparative Genomic Hybridization
  • CGH
  • Chromosomal Microarray
  • CMA
  • Microarray
  • oncology, formalin-fixed, paraffin-embedded, FFPE
  • Single-nucleotide-polymorphism (SNP) array
  • tissue
  • tumor
  • Whole Genome Array
Cytogenomic Molecular Inversion Probe Array, FFPE Tissue - Oncology