Ordering Recommendation

Recommended test to confirm a diagnosis of hereditary renal cancer syndrome in individuals with personal or family history of renal cancer. When a relative has a previously identified pathogenic variant, see Familial Mutation, Targeted Sequencing (2001961).

Mnemonic
RENCAPAN
Methodology

Massively Parallel Sequencing/Exonic Oligonucleotide-based CGH Microarray

Performed

Varies

Reported

3-6 weeks

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Lavender (EDTA) or yellow (ACD Solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Statement C: For human genetic inheritable conditions and mutations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Note

Genes Tested: BAP1, DICER1, FH, FLCN, MET, MLH1, MSH2, MSH6, PMS2, PTEN, SDHB, SDHC*, SDHD*, SMARCA4**, SMARCB1, TP53, TSC1, TSC2, VHL, WT1**
 
* One or more exons are not covered by sequencing for the indicated gene; see Additional Technical Information.
** Deletion/duplication detection is not available for this gene.

Hotline History
N/A
Components
Component Test Code* Component Chart Name LOINC
2010215 Renal Hereditary Cancer Panel Specimen 31208-2
2010218 Renal Hereditary Cancer Panel Interp 41103-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Birt-Hogg-Dube syndrome
  • Cowden syndrome
  • Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) syndrome
  • Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
  • Hereditary Papillary Renal Carcinoma (HPRC)
  • Hereditary Paraganglioma Pheochromocytoma syndrome
  • Li-Fraumeni syndrome (LFS)
  • Lynch syndrome
  • Malignant Mesothelioma
  • PTEN Hamartoma Tumor syndrome
  • Rhabdoid Tumor Predisposition syndrome
  • Tuberous Sclerosis Complex (TSC)
  • Von Hippel Lindau (VHL) syndrome
  • Wilms tumor
Hereditary Renal Cancer Panel, Sequencing and Deletion/Duplication