RUNX1-RUNX1T1 (AML1-ETO) t(8;21) Detection, Quantitative

2010138
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Example Reports
Detected
Not Detected
Weak Positive

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Time Sensitive

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Additional Technical Information

Ordering Recommendation

Use to detect and quantitate RUNX1-RUNX1T1 fusions arising from t(8;21). Use to monitor for minimal residual disease and assess the risk of disease relapse. 

Mnemonic

AML1-ETO Q

Methodology

Reverse Transcription Polymerase Chain Reaction

Performed

Varies

Reported

5-9 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Whole blood or bone marrow in lavender (EDTA).

Specimen Preparation

Whole Blood: Transport 5 mL whole blood. (Min: 3 mL)
Bone Marrow: Transport 3 mL bone marrow. (Min: 1 mL)
Refrigerate immediately. Specimens must be received within 48 hours of collection due to lability of RNA.

Storage/Transport Temperature

Whole Blood or Bone Marrow: CRITICAL REFRIGERATED. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum, plasma, ambient or frozen bone marrow or whole blood, CSF, or FFPE tissue. Specimens collected in anticoagulants other than EDTA. Severely hemolyzed or clotted specimens.
Ambient whole blood and ambient bone marrow specimens past 7 days will be canceled. Refrigerated whole blood or bone marrow past 7 days will be canceled.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: Unacceptable

Reference Interval

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
11/14/2022
X
X
08/15/2022
X
N/A

CPT Codes

81401

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Components

Component Test Code* Component Chart Name LOINC
2010139 RUNX1-RUNX1T1 Result 21819-8
2010140 RUNX1-RUNX1T1/ABL1 Ratio 21793-5
3003497 RUNX1-RUNX1T1 Source
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • t(8;21) (RUNX1-RUNX1T1 (AML1-ETO) t(8;21) Detection, Quantitative)
RUNX1-RUNX1T1 (AML1-ETO) t(8;21) Detection, Quantitative