Ordering Recommendation

May be useful as an independent risk marker for thrombosis associated with APS and related diseases. Consider using when all criteria aPL antibody tests are negative; positive results should be reported to document persistence.

Mnemonic

APS/PT PAN

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Thu

Reported

1-8 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube. Also acceptable: Blue (sodium citrate).

Specimen Preparation

Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.15 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Frozen.

Unacceptable Conditions

Other body fluids. Contaminated, hemolyzed, grossly icteric, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Available
Separately
Component Reference Interval
2009448 Phosphatidylserine and Prothrombin IgG 0-30 Units
No Phosphatidylserine and Prothrombin IgM 0-30 Units

Interpretive Data

The presence of elevated and persistent aPS/PT IgG and IgM antibodies (with or without lupus anticoagulant activity) may serve as a risk marker of thrombotic events in patients with certain autoimmune diseases, including antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). Strong clinical correlation is recommended for isolated IgM aPS/PT antibody.

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

83516 x2

Components

Component Test Code* Component Chart Name LOINC
2009448 Phosphatidylserine and Prothrombin IgG
2009450 Phosphatidylserine and Prothrombin IgM
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Phosphatidylserine and Prothrombin Antibodies, IgG and IgM