Ordering Recommendation

Preferred test to confirm diagnosis of pulmonary arterial hypertension (PAH), especially in those with a family history of PAH.

New York DOH Approval Status

Testing is not New York state approved. Specimens from New York clients will be sent out to a New York state-approved laboratory.

Specimen Required

Patient Preparation

Lavender or pink (EDTA) or yellow (ACD solution A or B).
New York State Clients: Lavender (EDTA)

Specimen Preparation

Transport 3 mL whole blood. (Min: 3 mL)

Storage/Transport Temperature


Unacceptable Conditions

Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue.


Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable
New York State Clients: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: Unacceptable


Massively Parallel Sequencing




14-21 days

Reference Interval

By report

Interpretive Data

Refer to report.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Compliance Category

Laboratory Developed Test (LDT)


Genes tested: ACVRL1, BMPR2, CAV1, EIF2AK4, ENG,* GDF2, KCNA5, KCNK3, SMAD9, TBX4
One or more exons are not covered by deletion/duplication analysis for the indicated gene; see Additional Technical Information.

Hotline History


CPT Codes

81405; 81406; 81479


Component Test Code* Component Chart Name LOINC
2009346 PAH Pan. Seq/DelDup, Specimen 31208-2
2009349 PAH Pan. Seq/DelDup, Interp 49014-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • increased mean pulmonary artery pressure
  • PAH
  • pulmonary arterial hypertension
Pulmonary Arterial Hypertension (PAH) Panel, Sequencing and Deletion/Duplication