Ordering Recommendation

Useful in distinguishing lymphoplasmacytic lymphoma (LPL) from other low-grade B-cell lymphoproliferative disorders which may be in the differential diagnosis. Use when monitoring patients with LPL diagnosis and previously identified MYD88 L265P mutation.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Whole blood or bone marrow in lavender (EDTA) or FFPE tumor tissue.

Specimen Preparation

Whole Blood : Do not freeze. Transport 5 mL whole blood. (Min: 1 mL)
Bone Marrow : Do not freeze. Transport 3 mL bone marrow. (Min: 1 mL)
FFPE Tumor Tissue : Formalin-fixed (10 percent neutral buffered formalin) and paraffin-embedded tissue. Protect from excessive heat. Transport tissue in a tissue transport kit (ARUP Supply #47808) available online through eSupply using ARUP Connect(TM) or contact ARUP Client Services at 800-522-2787.

Storage/Transport Temperature

Whole Blood, Bone Marrow: Refrigerated
FFPE Tumor Tissue : Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Plasma, serum. Specimens collected in anticoagulants other than EDTA. Clotted or grossly hemolyzed specimens.
FFPE Tumor Tissue: Specimens fixed in any fixative other than 10 percent neutral buffered formalin.
Bone specimens submitted in non-EDTA decalcifier.


If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.


Whole Blood or Bone Marrow: Refrigerated: 7 days; Frozen: Unacceptable
FFPE Tumor Tissue: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable


Real-Time Polymerase Chain Reaction




5-10 days

Reference Interval

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
2009319 MYD88 Source 66746-9
2009320 MYD88 L265P Detection, Result
2009321 MYD88 L265P Detection, Quant 82140-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Lymphoplasmacytic lymphoma
  • Waldenstrom macroglobulinemia
MYD88 L265P Mutation Detection by PCR, Quantitative