MYD88 L265P Mutation Detection by PCR, Quantitative
Useful in distinguishing lymphoplasmacytic lymphoma (LPL) from other low-grade B-cell lymphoproliferative disorders which may be in the differential diagnosis. Use when monitoring patients with LPL diagnosis and previously identified MYD88 L265P mutation.
Real-Time Polymerase Chain Reaction
New York DOH Approval Status
Lavender (EDTA), bone marrow (EDTA), or FFPE tumor tissue.
Whole Blood : Do not freeze. Transport 5 mL whole blood. (Min: 1 mL)
Bone Marrow : Do not freeze. Transport 3 mL bone marrow. (Min: 1 mL)
FFPE Tumor Tissue : Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue in a tissue transport kit (ARUP Supply #47808) available online through eSupply using ARUP Connect ? or contact ARUP Client Services at 800-522-2787.
Whole Blood, Bone Marrow : Refrigerated.
FFPE Tumor Tissue : Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.
Whole Blood, Bone Marrow : Plasma, serum. Specimens collected in anticoagulants other than EDTA or sodium heparin. Clotted or grossly hemolyzed specimens.
FFPE Tumor Tissue : Specimens fixed/processed in alternative fixatives, heavy metal fixatives (B-4 or B-5), or tissue sections on slides. Decalcified specimens.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.
Whole Blood or Bone Marrow: Ambient: 24 hours; Refrigerated: 5 days; Frozen: Unacceptable
FFPE Tumor Tissue: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Refer to report.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|2009320||MYD88 L265P Detection, Result|
|2009321||MYD88 L265P Detection, Quant||82140-5|
- Lymphoplasmacytic lymphoma
- Waldenstrom macroglobulinemia