2009318
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MYD88 L265P Mutation Detection by PCR, Quantitative

MYD88
Example Reports
Detected
Not Detected

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Additional Technical Information

Ordering Recommendation

Useful in distinguishing lymphoplasmacytic lymphoma (LPL) from other low-grade B-cell lymphoproliferative disorders which may be in the differential diagnosis. Use when monitoring patients with LPL diagnosis and previously identified MYD88 L265P mutation.

Methodology

Real-Time Polymerase Chain Reaction

Performed

Varies

Reported

5-10 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA), bone marrow (EDTA), or FFPE tumor tissue.

Specimen Preparation

Whole Blood : Do not freeze. Transport 5 mL whole blood. (Min: 1 mL)
Bone Marrow : Do not freeze. Transport 3 mL bone marrow. (Min: 1 mL)
FFPE Tumor Tissue : Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue in a tissue transport kit (ARUP Supply #47808) available online through eSupply using ARUP Connect ? or contact ARUP Client Services at 800-522-2787.

Storage/Transport Temperature

Whole Blood, Bone Marrow : Refrigerated.
FFPE Tumor Tissue : Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Whole Blood, Bone Marrow : Plasma, serum. Specimens collected in anticoagulants other than EDTA or sodium heparin. Clotted or grossly hemolyzed specimens.
FFPE Tumor Tissue : Specimens fixed/processed in alternative fixatives, heavy metal fixatives (B-4 or B-5), or tissue sections on slides. Decalcified specimens.

Remarks

If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.

Stability

Whole Blood or Bone Marrow: Ambient: 24 hours; Refrigerated: 5 days; Frozen: Unacceptable
FFPE Tumor Tissue: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
11/14/2022
X
N/A

CPT Codes

81305

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Components

Component Test Code* Component Chart Name LOINC
2009319 MYD88 Source 66746-9
2009320 MYD88 L265P Detection, Result
2009321 MYD88 L265P Detection, Quant 82140-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Lymphoplasmacytic lymphoma
  • Waldenstrom macroglobulinemia
MYD88 L265P Mutation Detection by PCR, Quantitative