Ordering Recommendation

Qualitative test to monitor medication compliance and to detect undisclosed drug/substance use in support of pain management, substance use disorders treatment, and other pharmacotherapies involving controlled substances. Expert result interpretation is provided by a faculty clinical toxicologist.

Submission of a medication history is required to optimize reporting; refer to ARUP's Medication Submission Guidelines for details. If a medication history is not available or interpretation is not desired, refer to Drug Profile, Targeted by Tandem Mass Spectrometry and Enzyme Immunoassay, Urine (2007479).

This test does not distinguish between the delta-8 and delta-9 forms of THC or their metabolites.




Quantitative Liquid Chromatography-Tandem Mass Spectrometry/Qualitative Enzyme Multiplied Immunoassay Technique (EMIT)/Quantitative Spectrophotometry




1-4 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Information on the patient's current medications must be submitted with the order. Include trade name, generic name, dosing frequency and date of last dose, if known. Alternatively, please indicate if no prescription medication or drugs are being taken.


Random urine.

Specimen Preparation

Transfer 4 mL each into two (2) ARUP Standard Transport Tubes urine with no additives or preservatives. (Min: 2 mL each)

Storage/Transport Temperature


Unacceptable Conditions

Specimens exposed to repeated freeze/thaw cycles.


Ambient: 1 week (Clonazepam may be unstable at ambient condition beyond three days); Refrigerated: 1 month; Frozen: 1 month

Reference Interval

Drugs covered and range of cutoff concentrations.
Note: Some drugs are identified based on the presence of unique drug metabolites not listed below.
Drugs/Drug Classes
Range of Cutoff Concentrations
Barbiturates 200 ng/mL
alprazolam, clonazepam, diazepam, lorazepam, midazolam, nordiazepam, oxazepam,  temazepam, zolpidem
20 - 60 ng/mL
Cannabinoids (11-nor-9-carboxy-THC) 50 ng/mL
Ethyl Glucuronide 500 ng/mL
Muscle Relaxant(s):
carisoprodol, meprobamate
100 ng/mL
buprenorphine, codeine, fentanyl, heroin, hydrocodone, hydromorphone, meperidine, methadone, morphine, naloxone, oxycodone, oxymorphone, tapentadol, tramadol
2-200 ng/mL
GABA analogues:
Gabapentin, pregabalin
3,000 ng/mL
Phencyclidine (PCP) 25 ng/mL
amphetamine, cocaine, methamphetamine, methylphenidate, MDMA (Ecstasy), MDEA (Eve), MDA, phentermine
50-200  ng/mL

Interpretive Data

Methodology: Qualitative Enzyme Immunoassay and Qualitative Liquid Chromatography-Tandem Mass Spectrometry, Quantitative Spectrophotometry

The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration must be greater than or equal to the cutoff concentration to be reported as present. If specific drug concentrations are required, contact the laboratory within two weeks of specimen collection to request confirmation and quantification by a second analytical technique. Interpretive questions should be directed to the laboratory.

Results based on immunoassay detection that do not match clinical expectations should be interpreted with caution. Confirmatory testing by mass spectrometry for immunoassay-based results is available if ordered within two weeks of specimen collection. Additional charges apply.

For medical purposes only; not valid for forensic use. 

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Creatinine concentration is also provided. The carisoprodol immunoassay has cross-reactivity to carisoprodol and meprobamate.

Hotline History


CPT Codes

80326; 80347; 80364; 80355; 80307 (Alt code: G0481)


Component Test Code* Component Chart Name LOINC
0090386 Creatinine, Urine 2161-8
2007636 Codeine (cutoff 40 ng/mL) 3507-1
2007637 Morphine (cutoff 20 ng/mL) 3830-7
2007638 6-acetylmorphine (cutoff 20 ng/mL) 10976-9
2007640 Oxycodone (cutoff 40 ng/mL) 10998-3
2007641 Noroxycodone (cutoff 100 ng/mL) 61424-8
2007642 Oxymorphone (cutoff 40 ng/mL) 11247-4
2007643 Noroxymorphone (cutoff 100 ng/mL) 89302-4
2007644 Hydrocodone (cutoff 40 ng/mL) 12308-3
2007646 Norhydrocodone (cutoff 100 ng/mL) 61421-4
2007647 Hydromorphone (cutoff 20 ng/mL) 9834-3
2007649 Buprenorphine (cutoff 5 ng/mL) 3414-0
2007651 Norbuprenorphine (cutoff 20 ng/mL) 58362-5
2007652 Fentanyl (cutoff 2 ng/mL) 11235-9
2007653 Norfentanyl (cutoff 2 ng/mL) 43199-9
2007654 Meperidine metabolite (cutoff 50 ng/mL) 58388-0
2007655 Tapentadol (cutoff 100 ng/mL) 72485-6
2007656 Tapentadol-o-Sulf (cutoff 200 ng/mL) 72485-6
2007658 Methadone (cutoff 150 ng/mL) 3773-9
2007660 Tramadol (cutoff 100 ng/mL) 43219-5
2007662 Amphetamine (cutoff 50 ng/mL) 19343-3
2007663 Methamphetamine (cutoff 200 ng/mL) 3779-6
2007664 MDMA- Ecstasy (cutoff 200 ng/mL) 14267-9
2007665 MDA (cutoff 200 ng/mL) 42253-5
2007666 MDEA- Eve (cutoff 200 ng/mL) 61048-5
2007668 Phentermine (cutoff 100 ng/mL) 3957-8
2007670 Benzoylecgonine (cutoff 150 ng/mL) 3393-6
2007672 Alprazolam (cutoff 40 ng/mL) 9351-8
2007673 Alpha-OH-Alprazolam (cutoff 20 ng/mL) 61036-0
2007674 Clonazepam (cutoff 20 ng/mL) 19245-0
2007675 7-Aminoclonazepam (cutoff 40 ng/mL) 61030-3
2007676 Diazepam (cutoff 50 ng/mL) 3550-1
2007677 Nordiazepam (cutoff 50 ng/mL) 3861-2
2007678 Oxazepam (cutoff 50 ng/mL) 12361-2
2007679 Temazepam (cutoff 50 ng/mL) 61060-0
2007680 Lorazepam (cutoff 60 ng/mL) 18187-5
2007681 Midazolam (cutoff 20 ng/mL) 19585-9
2007682 Zolpidem (cutoff 20 ng/mL) 33338-5
2007684 Barbiturates (cutoff 200 ng/mL) 3377-9
2007687 Ethyl Glucuronide (cutoff 500 ng/mL) 55349-5
2007688 Marijuana Metabolite 3435-5
2007689 PCP (cutoff 25 ng/mL) 3936-2
2007690 Carisoprodol (cut-off 100 ng/mL) 21142-5
2007691 Targeted drug profile panel 8251-1
2009289 EER Tgt drug prof, MS/EMIT, UR, Interp 11526-1
2009290 DRUGS EXPECTED 48767-8
2009291 Targeted drug profile Interp 48767-8
2013281 Methylphenidate (cutoff 100 ng/mL) 3808-3
3003499 Alpha-OH-Midazolam (cutoff 20 ng/mL) 94108-8
3003500 Zolpidem Metabolite (cutoff 100 ng/mL) 94103-9
3003501 Gabapentin (cutoff 3,000 ng/mL) 92648-5
3003502 Naloxone (cutoff 100 ng/mL) 92649-3
3003503 Pregabalin (cutoff 3,000 ng/mL) 92651-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • abstinence verification
  • addiction management
  • Comprehensive hybrid
  • high res
  • high-res
  • hybrid
  • medication adherence
  • medication compliance
  • Pain management, (drug screen, targeted, urine)
  • prenatal drug screen
  • substance use disorder
Drug Profile, Targeted with Interpretation by Tandem Mass Spectrometry and Enzyme Immunoassay, Urine