Ordering Recommendation

Not a preferred test. Refer to relevant test for the specific pathogen suspected.

Mnemonic

ENCEPH

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Chemiluminescent Immunoassay

Performed

Sun-Sat

Reported

2-6 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Refer to individual components. CSF (refer to Encephalitis Panel with Reflex to Herpes Simplex Virus Types 1 and 2 Glycoprotein G-Specific Antibodies, IgG, CSF, test code 2008916).

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

Test Number
Components
Reference Interval
  HSV 1 and/or 2 Abs, IgM by ELISA 0.89 IV or less
  West Nile Virus Ab, IgG, Ser 1.29 IV or less
  West Nile Virus Ab, IgM, Ser 0.89 IV or less
  Mumps Virus Antibody, IgM 0.79 IV or less
  Measles, Rubeola, Antibody IgM 0.79 AU or less
  Varicella-Zoster Virus Antibody, IgM 0.90 ISR or less

Interpretive Data




Component Interpretation
Measles (Rubeola) Antibody, IgG 13.4 AU/mL or less: Negative - No significant level of detectable measles (rubeola) IgG antibody.
13.5-16.4 AU/mL: Equivocal - Repeat testing in 10-14 days may be helpful.
16.5 AU/mL or greater: Positive - IgG antibody to measles (rubeola) detected, which may indicate a current or past exposure/immunization to measles (rubeola).
Measles (Rubeola) Antibody, IgM 0.79 AU or less: Negative - No significant level of IgM antibodies to measles (rubeola) virus detected.
0.80-1.20 AU: Equivocal - Repeat testing in 10-14 days may be helpful.
1.21 AU or greater: Positive - IgM antibodies to measles (rubeola) virus detected. Suggestive of current or recent infection or immunization. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection or immunization.
Mumps Virus Antibody, IgG 8.9 AU/mL or less: Negative - No significant level of detectable IgG mumps virus antibody.
9.0-10.9 AU/mL: Equivocal - Repeat testing in 10-14 days may be helpful.
11.0 AU/mL or greater: Positive - IgG antibody to mumps virus detected, which may indicate a current or past exposure/immunization to mumps virus.
Mumps Virus Antibody, IgM 0.79 IV or less: Negative - No significant level of detectable IgM antibody to Mumps virus.
0.80-1.20 IV: Equivocal - Borderline levels of IgM antibody to Mumps virus. Repeat testing in 10-14 days may be helpful.
1.21 IV or greater: Positive - Presence of IgM antibody to Mumps virus detected, which may indicate a current or recent infection. However, low levels of IgM antibody may occasionally persist for more than 12 months post-infection or immunization.
Varicella-Zoster Virus Antibody, IgG 134.9 IV or less: Negative - No significant level of detectable varicella-zoster IgG antibody.
135.0-164.9 IV: Equivocal - Repeat testing in 10-14 days may be helpful.
165.0 IV or greater: Positive - IgG antibody to varicella-zoster detected, which may indicate a current or past varicella-zoster infection.
Varicella-Zoster Virus Antibody, IgM 0.90 ISR or less: Negative - No significant level of detectable varicella-zoster virus IgM antibody.
0.91-1.09 ISR: Equivocal - Repeat testing in 10-14 days may be helpful.
1.10 ISR or greater: Positive - Significant level of detectable varicella-zoster virus IgM antibody. Indicative of current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection or immunization.
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgM by ELISA 0.89 IV or less:  Not Detected.
0.90-1.09 IV:  Indeterminate - Repeat testing in 10-14 days may be helpful.
1.10 IV or greater:  Detected - IgM antibody to HSV detected, which may indicate a current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG 0.89 IV or less:  Not Detected.
0.90-1.09 IV:  Indeterminate - Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Detected.
West Nile Virus Antibody, IgG by ELISA, Serum 1.29 IV or less: Negative - No significant level of West Nile virus IgG antibody detected.
1.30-1.49 IV: Equivocal - Questionable presence of West Nile virus IgG antibody detected. Repeat testing in 10-14 days may be helpful.
1.50 IV or greater: Positive - Presence of IgG antibody to West Nile virus detected, suggestive of current or past infection.
West Nile Virus Antibody, IgM by ELISA, Serum 0.89 IV or less: Negative - No significant level of West Nile virus IgM antibody detected.
0.90-1.10 IV: Equivocal - Questionable presence of West Nile virus IgM antibody detected. Repeat testing in 10-14 days may be helpful.
1.11 IV or greater: Positive - Presence of IgM antibody to West Nile virus detected, suggestive of current or recent infection.

Compliance Category

FDA

Note

If HSV 1 and/or 2 IgG is 1.10 IV or greater, then HSV 1 G-Specific IgG and HSV 2 G-Specific IgG will be added. Additional charges apply.

Hotline History

N/A

CPT Codes

86765 x2; 86735 x2; 86787 x2; 86789; 86788; 86694 x2; if reflexed, add 86695; 86696

Components

Component Test Code* Component Chart Name LOINC
0050167 Varicella-Zoster Virus Ab, IgG 5403-1
0050234 West Nile Virus Ab, IgG, Ser 38997-3
0050236 West Nile Virus Ab, IgM, Ser 38166-5
0050286 HSV Type 1/2 Combined Ab, IgG 27948-9
0050380 Measles, Rubeola, Antibody IgG 7962-4
0050390 Mumps Virus Antibody, IgG 25418-5
0050641 HSV 1 and/or 2 Abs, IgM by ELISA 41399-7
0099314 Varicella-Zoster Virus Antibody, IgM 5404-9
0099589 Mumps Virus Antibody, IgM 25419-3
0099597 Measles, Rubeola, Antibody IgM 25421-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Encephalitis Panel with Reflex to Herpes Simplex Virus Types 1 and 2 Glycoprotein G-Specific Antibodies, IgG, Serum