Ordering Recommendation

Not a preferred test. Refer to relevant test for the specific pathogen suspected.

Mnemonic
ENCEPH
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Chemiluminescent Immunoassay

Performed

Sun-Sat

Reported

2-6 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Refer to individual components. CSF (refer to Encephalitis Panel with Reflex to Herpes Simplex Virus Types 1 and 2 Glycoprotein G-Specific Antibodies, IgG, CSF, test code 2008916).

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval
Test Number
Components
Reference Interval
0050380 Measles (Rubeola) Antibody, IgG Effective September 3, 2019

13.4 AU/mL or less: Negative - No significant level of detectable measles (rubeola) IgG antibody.
13.5-16.4 AU/mL: Equivocal - Repeat testing in 10-14 days may be helpful.
16.5 AU/mL or greater: Positive - IgG antibody to measles (rubeola) detected, which may indicate a current or past exposure/immunization to measles (rubeola).
0099597 Measles (Rubeola) Antibody, IgM 0.79 AU or less: Negative - No significant level of IgM antibodies to measles (rubeola) virus detected.
0.80-1.20 AU: Equivocal - Repeat testing in 10-14 days may be helpful.
1.21 AU or greater: Positive - IgM antibodies to measles (rubeola) virus detected. Suggestive of current or recent infection or immunization. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection or immunization.
0050390 Mumps Virus Antibody, IgG Effective August 20, 2012

8.9 AU/mL or less: Negative - No significant level of detectable IgG mumps virus antibody.
9.0-10.9 AU/mL: Equivocal - Repeat testing in 10-14 days may be helpful.
11.0 AU/mL or greater: Positive - IgG antibody to mumps virus detected, which may indicate a current or past exposure/immunization to mumps virus.
0099589 Mumps Virus Antibody, IgM 0.79 IV or less: Negative - No significant level of detectable IgM antibody to Mumps virus.
0.80-1.20 IV: Equivocal - Borderline levels of IgM antibody to Mumps virus. Repeat testing in 10-14 days may be helpful.
1.21 IV or greater: Positive - Presence of IgM antibody to Mumps virus detected, which may indicate a current or recent infection. However, low levels of IgM antibody may occasionally persist for more than 12 months post-infection or immunization.
0050167 Varicella-Zoster Virus Antibody, IgG Effective February 18, 2020

134.9 IV or less: Negative - No significant level of detectable varicella-zoster IgG antibody.
135.0-164.9 IV: Equivocal - Repeat testing in 10-14 days may be helpful.
165.0 IV or greater: Positive - IgG antibody to varicella-zoster detected, which may indicate a current or past varicella-zoster infection.
0099314 Varicella-Zoster Virus Antibody, IgM 0.90 ISR or less: Negative - No significant level of detectable varicella-zoster virus IgM antibody.
0.91-1.09 ISR: Equivocal - Repeat testing in 10-14 days may be helpful.
1.10 ISR or greater: Positive - Significant level of detectable varicella-zoster virus IgM antibody. Indicative of current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection or immunization.
0050641 Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgM by ELISA
0.89 IV or less: Not Detected.
0.90-1.09 IV: Indeterminate - Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Detected - IgM antibody to HSV detected, which may indicate a current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.

0050292 Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by CIA
Effective February 18, 2020
0.89 IV or less Negative - No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
0.90-1.09 IV Equivocal - Questionable presence of IgG antibody to HSV type 1 glycoprotein G. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater Positive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past HSV infection.

0050294 Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by CIA
Effective February 18, 2020
0.89 IV or less Negative - No significant level of detectable IgG antibody to HSV type 2 glycoprotein G.
0.90-1.09 IV Equivocal - Questionable presence of IgG antibody to HSV type 2 glycoprotein G.  Repeat testing in 10-14 days may be helpful.
1.10 IV or greater Positive - IgG antibody to HSV type 2 glycoprotein G detected, which may indicate a current or past HSV infection.

0050293 Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG
0.89 IV or less: Not Detected.
0.90-1.09 IV: Indeterminate - Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Detected.

0050234 West Nile Virus Antibody, IgG by ELISA, Serum 1.29 IV or less: Negative - No significant level of West Nile virus IgG antibody detected.
1.30-1.49 IV: Equivocal - Questionable presence of West Nile virus IgG antibody detected. Repeat testing in 10-14 days may be helpful.
1.50 IV or greater: Positive - Presence of IgG antibody to West Nile virus detected, suggestive of current or past infection. 
0050236 West Nile Virus Antibody, IgM by ELISA, Serum 0.89 IV or less: Negative - No significant level of West Nile virus IgM antibody detected.
0.90-1.10 IV: Equivocal - Questionable presence of West Nile virus IgM antibody detected. Repeat testing in 10-14 days may be helpful.
1.11 IV or greater: Positive - Presence of IgM antibody to West Nile virus detected, suggestive of current or recent infection. 

Interpretive Data



No compliance statements are in use for this test.

Note

If HSV 1 and/or 2 IgG is 1.10 IV or greater, then HSV 1 G-Specific IgG and HSV 2 G-Specific IgG will be added. Additional charges apply.

Hotline History
N/A
CPT Codes

86765 x2; 86735 x2; 86787 x2; 86789; 86788; 86694 x2; if reflexed, add 86695; 86696

Components
Component Test Code* Component Chart Name LOINC
0050167 Varicella-Zoster Virus Ab, IgG 5403-1
0050234 West Nile Virus Ab, IgG, Ser 38997-3
0050236 West Nile Virus Ab, IgM, Ser 38166-5
0050286 HSV Type 1/2 Combined Ab, IgG 27948-9
0050380 Measles, Rubeola, Antibody IgG 7962-4
0050390 Mumps Virus Antibody, IgG 25418-5
0050641 HSV 1 and/or 2 Abs, IgM by ELISA 41399-7
0099314 Varicella-Zoster Virus Antibody, IgM 5404-9
0099589 Mumps Virus Antibody, IgM 25419-3
0099597 Measles, Rubeola, Antibody IgM 25421-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Encephalitis Panel with Reflex to Herpes Simplex Virus Types 1 and 2 Glycoprotein G-Specific Antibodies, IgG, Serum