Ordering Recommendation

Identifies and quantifies CD57+/CD3- NK cells.




Flow Cytometry




1-3 days
1-3 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation

Lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).

Specimen Preparation

Transport 4 mL whole blood. (Min: 0.5 mL) Specimens must be analyzed within 72 hours of collection.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated.

Unacceptable Conditions

Specimens older than 72 hours. Clotted or hemolyzed specimens.


Ambient: 72 hours; Refrigerated: 72 hours; Frozen: Unacceptable

Reference Interval

Available Separately
Reference Interval
No Percent CD57+CD3- (NK Cells) 1-16 percent of lymph
No Abs CD57+CD3- (NK Cells) 21-357 cells/µL

Interpretive Data

This test identifies and quantifies the CD57+/CD3- NK cells. The significance of low CD57+NK values in diagnosing and monitoring chronic Lyme disease is not well established and should be used in conjunction with other diagnostic tests specified in the Centers for Disease Control Lyme Disease case definition.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Analyte Specific Reagent (ASR)


Hotline History


CPT Codes

86356 x2


Component Test Code* Component Chart Name LOINC
2008913 % CD57+CD3- (NK Cells) 51286-3
2008914 Abs CD57+CD3- (NK Cells) 50640-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


CD57+ NK Cells, Peripheral Blood by Flow Cytometry