Ordering Recommendation

Use for pretherapeutic identification of individuals who may require higher or lower doses of opioid drugs to achieve adequate pain control. May also be used to optimize naltrexone treatment for alcohol and/or opioid dependency.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or serum. Heparinized specimens. Frozen specimens in glass collection tubes.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month

Methodology

Polymerase Chain Reaction (PCR)/Fluorescence Monitoring

Performed

Varies

Reported

5-10 days

Reference Interval

By report.

Interpretive Data

Refer to report

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

81479

Components

Component Test Code* Component Chart Name LOINC
2008768 OPRM1, Specimen 66746-9
2008769 OPRM1 Genotype, Interpretation 94415-7
3005505 OPRM1 Phenotype, Interpretation 81259-4
3005508 OPRM1, Interpretation 50398-7
3016894 EER Opioid Receptor, mu OPRM1 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Opioid receptor sensitivity (Opioid Receptor, Mu (OPRM1) Genotype, 1 Variant)
Opioid Receptor, mu OPRM1, 1 Variant