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Chromosome Analysis, Amniotic Fluid, with Reflex to Genomic Microarray
Ordering Recommendation
Use to test amniotic fluid for the following indications:
- Abnormal US findings
- Abnormal prenatal screen
- Fetal demise
Genomic microarray testing is performed on normal chromosome analysis results. In cases with a normal karyotype, microarray studies reveal clinically relevant copy number variations (CNV) in approximately 6% of fetuses with an ultrasound anomaly and approximately 2% whose indication is advanced maternal age or positive aneuploidy screen.
New York DOH Approval Status
Specimen Required
N/A
Amniotic fluid.
Do not freeze or expose to extreme temperatures. Transport 15-30 mL amniotic fluid in a sterile container.
Room temperature.
N/A
Ambient: 48 hours; Refrigerated: 48 hours Frozen: Unacceptable
Methodology
Giemsa Band/Genomic Microarray (Oligo-SNP Array)
Performed
Sun-Sat
Reported
7-14 days
If reflexed, add 5-7 days.
Reference Interval
By report
Interpretive Data
Refer to report
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Counseling and informed consent are recommended for genetic testing. Consent forms are available online.
Laboratory Developed Test (LDT)
Note
If Chromosome Analysis is "normal" or "no growth," then Genomic Microarray testing will be added. Additional charges apply.
Maternal cell contamination studies recommended if testing reflexes to the fetal microarray. For maternal cell contamination studies if testing reflexes to the fetal microarray, please submit a maternal blood sample and order Maternal Cell Contamination, Maternal Specimen (ARUP test code 0050608), accompanied by a test request form for the mother (this test is performed at no charge as part of the fetal microarray). Maternal blood should be submitted along with the amniotic fluid sample at the time the test ordered. For questions regarding ordering please contact ARUP's genetic counselor at (800) 242-2787 ext. 2141.
The chromosome analysis studies involve culturing of living cells; therefore, turnaround times given represent average times, which are subject to multiple variables.
A processing fee will be charged if this procedure is canceled at the client's request after the test has been set up or if the specimen integrity is inadequate to allow culture growth
This test must be ordered using Cytogenetic test request form 43098 or through your ARUP interface. Please submit the Patient History for Prenatal Cytogenetics form with the electronic packing list (https://ltd.aruplab.com/Tests/Pdf/65). Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com.
Hotline History
CPT Codes
88269; 88235; if reflexed, add 81229; 81265
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0097601 | Chromosome Analysis, Amniotic Fluid | 33773-3 |
| 2009476 | EER Chrom Analysis AF w/Rflx to Array | 11502-2 |
Aliases
- Amniotic Fluid, Chromosome Analysis
- Array CGH, Prenatal
- comparative genomic hybridization, prenatal
- Karyotype, Amniotic Fluid
- prenatal
- Prenatal array
- Prenatal Chromosomes, Amniotic Fluid
- Prenatal Diagnosis
