Ordering Recommendation

Use to test amniotic fluid for the following indications:
Abnormal US findings
Abnormal prenatal screen
Fetal demise
Genomic microarray testing is performed on normal chromosome analysis results.  In cases with a normal karyotype, microarray studies reveal clinically relevant copy number variations (CNV) in ~6% of fetuses with an ultrasound anomaly and ~2% whose indication is advanced maternal age or positive aneuploidy screen.

New York DOH Approval Status

Testing is not New York state approved. Specimens from New York clients will be sent out to a New York state-approved laboratory.

Specimen Required

Patient Preparation



Amniotic fluid.

Specimen Preparation

Do not freeze or expose to extreme temperatures. Transport 15-30 mL amniotic fluid in a sterile container.

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions



Ambient: 48 hours; Refrigerated: 48 hours Frozen: Unacceptable


Giemsa Band/Genomic Microarray (Oligo-SNP Array)




7-14 days
If reflexed, add 5-7 days.

Reference Interval

By report

Interpretive Data

Refer to report

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Compliance Category

Laboratory Developed Test (LDT)


If Chromosome Analysis is "normal" or "no growth,"  then Genomic Microarray testing will be added.  Additional charges apply.

Maternal cell contamination studies recommended if testing reflexes to the fetal microarray. For maternal cell contamination studies if testing reflexes to the fetal microarray, please submit a maternal blood sample and order Maternal Cell Contamination, Maternal Specimen (ARUP test code 0050608), accompanied by a test request form for the mother (this test is performed at no charge as part of the fetal microarray). Maternal blood should be submitted along with the amniotic fluid sample at the time the test ordered. For questions regarding ordering please contact ARUP's genetic counselor at (800) 242-2787 ext. 2141.

The chromosome analysis studies involve culturing of living cells; therefore, turnaround times given represent average times, which are subject to multiple variables.

A processing fee will be charged if this procedure is canceled at the client's request after the test has been set up or if the specimen integrity is inadequate to allow culture growth

This test must be ordered using Cytogenetic test request form 43098 or through your ARUP interface. Please submit the Patient History for Prenatal Cytogenetics form with the electronic packing list (https://ltd.aruplab.com/Tests/Pdf/65). Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com.

Hotline History


CPT Codes

88269; 88235; if reflexed, add 81229; 81265


Component Test Code* Component Chart Name LOINC
0097601 Chromosome Analysis, Amniotic Fluid 33773-3
2009476 EER Chrom Analysis AF w/Rflx to Array 11502-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Amniotic Fluid, Chromosome Analysis
  • Array CGH, Prenatal
  • comparative genomic hybridization, prenatal
  • Karyotype, Amniotic Fluid
  • prenatal
  • Prenatal array
  • Prenatal Chromosomes, Amniotic Fluid
  • Prenatal Diagnosis
Chromosome Analysis, Amniotic Fluid, with Reflex to Genomic Microarray