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Celiac Disease Reflexive Cascade
Ordering Recommendation
Preferred reflex screening test for celiac disease and dermatitis herpetiformis. May aid in monitoring adherence to gluten-free diet.
Methodology
Quantitative Immunoturbidimetry/Semi-Quantitative Enzyme-Linked Immunosorbent Assay//Semi-Quantitative Indirect Fluorescent Antibody
Performed
Sun-Sat
Reported
2-6 days
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1.5 mL)
Refrigerated.
Plasma. Contaminated, hemolyzed, grossly icteric or grossly lipemic specimens.
After separation from cells: Ambient: Unacceptable; Refrigerated: 14 days; Frozen: 6 months (avoid repeated freeze/thaw cycles)
Reference Interval
| Test Number |
Components |
Reference Interval |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Immunoglobulin A |
|
Interpretive Data
Refer to report.
FDA
Note
The Celiac Disease Reflexive Cascade begins with Immunoglobulin A. Depending on findings, one or more reflexive tests may be required in order to provide a clinical interpretation. Tests added may include Tissue Transglutaminase Antibody, IgA; Tissue Transglutaminase Antibody, IgG; Endomysial Antibody, IgA by IFA; Deamidated Gliadin Peptide (DGP) Antibody, IgA; Deamidated Glaidin Peptide (DGP) Antibody, IgG; and/or Celiac Disease Dual Antigen Screen. Refer to the Celiac Testing Algorithm found at https://www.arupconsult.com/Algorithms/CeliacDz.pdf. Additional charges apply.
Hotline History
CPT Codes
82784; if reflexed additional CPT codes may apply: 83516; 86231; 86258 x2; 86364 x2
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050340 | Immunoglobulin A | 2458-8 |
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