2007967
print

Motor and Sensory Neuropathy Evaluation with Immunofixation Electrophoresis and Reflex to Titer and Neuronal Immunoblot

MSNCR
Example Reports
Abnormal
Enhanced Report
Normal

Ordering Recommendation

Aids in diagnosis of combined motor/sensory neuropathy when plasma cell dyscrasia or other malignancy is suspected.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube (SST).

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 5 mL serum to an ARUP standard transport tube. (Min: 2.5 mL)

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions

Plasma, CSF, or other body fluids. Contaminated, heat-inactivated, grossly hemolyzed, severely icteric, or lipemic specimens.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 1 month

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot/Quantitative Immunoturbidimetry/Quantitative Capillary Electrophoresis/Qualitative Immunofixation Electrophoresis/Colorimetry

Performed

Tue

Reported

3-9 days

Reference Interval

Test Number
 Components
 Reference Interval
  Alpha 1 Globulin 0.19-0.46 g/dL
  Alpha 2 Globulin 0.48-1.05 g/dL
  Beta Globulin 0.48-1.10 g/dL
  Gamma 0.62-1.51 g/dL
  Immunoglobulin A
Age Reference Interval (mg/dL)
0-2 years 2-126
3-4 years 14-212
5-9 years 52-226
10-14 years 42-345
15-18 years 60-349
19 years and older 68-408

  Immunoglobulin G
Age Reference Interval (mg/dL)
0-2 years 242-1108
3-4 years 485-1160
5-9 years 514-1672
10-14 years 581-1652
15-18 years 479-1433
19 years and older 768-1632

  Immunoglobulin M
Age Reference Interval (mg/dL)
0-2 years 21-215
3-4 years 26-155
5-9 years 26-188
10-14 years 47-252
15-18 years 26-232
19 years and older 35-263

  Total Protein, Serum Refer to report. Reference intervals may vary based on instrumentation.
  Asialo-GM1 Antibodies, IgG/IgM 0-50 IV
  GM1 Antibodies, IgG/IgM 0-50 IV
  GD1a Antibodies, IgG/IgM 0-50 IV
  GD1b Antibodies, IgG/IgM 0-50 IV
  GQ1b Antibodies, IgG/IgM 0-50 IV
  SGPG Antibody, IgM Less than 1.00 IV
  Monoclonal Protein <=0.00 g/dL

Interpretive Data




Components Interpretive Data
Asialo-GM1 Antibodies, IgG/IgM 29 IV or less: Negative
30-50 IV: Equivocal
51-100 IV: Positive
101 IV or greater: Strong Positive
GM1 Antibodies, IgG/IgM 29 IV or less: Negative
30-50 IV: Equivocal
51-100 IV: Positive
101 IV or greater: Strong Positive
GD1a Antibodies, IgG/IgM 29 IV or less: Negative
30-50 IV: Equivocal
51-100 IV: Positive
101 IV or greater: Strong Positive
GD1b Antibodies, IgG/IgM 29 IV or less: Negative
30-50 IV: Equivocal
51-100 IV: Positive
101 IV or greater: Strong Positive
GQ1b Antibodies, IgG/IgM 29 IV or less: Negative
30-50 IV: Equivocal
51-100 IV: Positive
101 IV or greater: Strong Positive

Compliance Category

Laboratory Developed Test (LDT)

Note

Purkinje cell (PCCA) antibody and neuronal nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/19/2024
X
N/A

CPT Codes

83516 x7; 82784 x3; 84155; 84165; 86334; 86255 if reflexed add 84182 x4 and/or 86256

Are you an ARUP Client? Click here for your pricing.

Components

Component Test Code* Component Chart Name LOINC
0050020 Albumin 2862-1
0050035 Alpha 1 Globulin 2865-4
0050060 Alpha 2 Globulin 2868-8
0050110 Beta Globulin 2871-2
0050270 Gamma 2874-6
0050271 Immunofixation 25700-6
0050340 Immunoglobulin A 2458-8
0050350 Immunoglobulin G 2465-3
0050355 Immunoglobulin M 2472-9
0050545 Total Protein, Serum 2885-2
0051034 Asialo-GM1 Antibodies, IgG/IgM 88723-2
0051035 GM1 Antibodies, IgG/IgM 31500-2
0051037 GD1a Antibodies, IgG/IgM 88724-0
0051038 GD1b Antibodies, IgG/IgM 88730-7
0051039 GQ1b Antibodies, IgG/IgM 88729-9
0051284 SGPG Antibody, IgM 31666-1
0051285 MAG Antibody, IgM Elisa 17314-6
2005168 SPEP/IFE Interpretation 49275-1
2007962 Purkinje Cell/Neuronal Nuclear IgG Scrn 61177-2
2011827 Monoclonal Protein 33358-3
2012458 EER Motor Sensory Neuropathy Comp 11502-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Motor and Sensory Neuropathy Evaluation with Immunofixation Electrophoresis and Reflex to Titer and Neuronal Immunoblot