Motor and Sensory Neuropathy Evaluation with Immunofixation Electrophoresis and Reflex to Titer and Neuronal Immunoblot
Ordering Recommendation
Aid in diagnosis of combined motor/sensory neuropathy when plasma cell dyscrasia or other malignancy is suspected.
Mnemonic
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot/Quantitative Immunoturbidimetry/Quantitative Capillary Electrophoresis/Qualitative Immunofixation Electrophoresis/Quantitative Spectrophotometry
Performed
Refer to individual components
Reported
3-9 days
New York DOH Approval Status
Specimen Required
Serum Separator Tube (SST).
Separate serum from cells ASAP or within 2 hours of collection. Transfer 5 mL serum to an ARUP Standard Transport Tube. (Min: 2.5 mL)
Refrigerated
Plasma, CSF, or other body fluids. Contaminated, heat-inactivated, grossly hemolyzed, severely icteric, or lipemic specimens.
Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 1 month
Reference Interval
Test Number |
Components |
Reference Interval |
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Albumin | 3.75-5.01 g/dL | ||||||||||||||||
Alpha 1 Globulin | 0.19-0.46 g/dL | ||||||||||||||||
Alpha 2 Globulin | 0.48-1.05 g/dL | ||||||||||||||||
Beta Globulin | 0.48-1.10 g/dL | ||||||||||||||||
Gamma | 0.62-1.51 g/dL | ||||||||||||||||
0050340 | Immunoglobulin A | Effective February 16, 2021
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0050350 | Immunoglobulin G | Effective February 16, 2021
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0050355 | Immunoglobulin M | Effective February 16, 2021
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Total Protein, Serum | August 19,2019 Refer to Report |
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Asialo-GM1 Antibodies, IgG/IgM |
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GM1 Antibodies, IgG/IgM |
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GD1a Antibodies, IgG/IgM |
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GD1b Antibodies, IgG/IgM |
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GQ1b Antibodies, IgG/IgM |
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0051284 | Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibody, IgM | Less than 1.00 IV | |||||||||||||||
0051285 | Myelin Associated Glycoprotein (MAG) Antibody, IgM | Less than 1000 TU | |||||||||||||||
2007961 | PCCA/ANNA by IFA with Reflex to Titer and Immunoblot | Effective August 17, 2020
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Interpretive Data
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. Additional charges apply.
Hotline History
Hotline History
CPT Codes
83516 x7; 82784 x3; 84155; 84165; 86334; 86255 if reflexed add 84182 x4 and/or 86256
Components
Component Test Code* | Component Chart Name | LOINC |
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0050020 | Albumin | 2862-1 |
0050035 | Alpha 1 Globulin | 2865-4 |
0050060 | Alpha 2 Globulin | 2868-8 |
0050110 | Beta Globulin | 2871-2 |
0050270 | Gamma | 2874-6 |
0050271 | Immunofixation | 25700-6 |
0050340 | Immunoglobulin A | 2458-8 |
0050350 | Immunoglobulin G | 2465-3 |
0050355 | Immunoglobulin M | 2472-9 |
0050545 | Total Protein, Serum | 2885-2 |
0051034 | Asialo-GM1 Antibodies, IgG/IgM | 88723-2 |
0051035 | GM1 Antibodies, IgG/IgM | 31500-2 |
0051037 | GD1a Antibodies, IgG/IgM | 88724-0 |
0051038 | GD1b Antibodies, IgG/IgM | 88730-7 |
0051039 | GQ1b Antibodies, IgG/IgM | 88729-9 |
0051284 | SGPG Antibody, IgM | 31666-1 |
0051285 | MAG Antibody, IgM Elisa | 17314-6 |
2005168 | SPEP/IFE Interpretation | 49275-1 |
2007962 | Purkinje Cell/Neuronal Nuclear IgG Scrn | 61177-2 |
2012458 | EER Motor Sensory Neuropathy Comp | 11502-2 |