Motor and Sensory Neuropathy Evaluation with Immunofixation Electrophoresis and Reflex to Titer and Neuronal Immunoblot

2007967
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Additional Technical Information
Ordering Recommendation

Aid in diagnosis of combined motor/sensory neuropathy when plasma cell dyscrasia or other malignancy is suspected.

Mnemonic
MSNCR
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot/Quantitative Immunoturbidimetry/Quantitative Capillary Electrophoresis/Qualitative Immunofixation Electrophoresis/Quantitative Spectrophotometry

Performed

Refer to individual components

Reported

3-9 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 5 mL serum to an ARUP Standard Transport Tube. (Min: 2.5 mL)

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions

Plasma, CSF, or other body fluids. Contaminated, heat-inactivated, grossly hemolyzed, severely icteric, or lipemic specimens.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 1 month

Reference Interval
Test Number
 Components
 Reference Interval
  Albumin 3.75-5.01 g/dL
  Alpha 1 Globulin 0.19-0.46 g/dL
  Alpha 2 Globulin 0.48-1.05 g/dL
  Beta Globulin 0.48-1.10 g/dL
  Gamma 0.62-1.51 g/dL
0050340 Immunoglobulin A Effective February 16, 2021
0-2 years: 2-126 mg/dL
3-4 years: 14-212 mg/dL
5-9 years: 52-226 mg/dL
10-14 years: 42-345 mg/dL
15-18 years: 60-349 mg/dL
19 years and older: 68-408 mg/dL

0050350 Immunoglobulin G Effective February 16, 2021
0-2 years: 242-1108 mg/dL            
3-4 years: 485-1160 mg/dL
5-9 years: 514-1672 mg/dL     
10-14 years: 581-1652 mg/dL                   
15-18 years: 479-1433 mg/dL                         
19 years and older : 768-1632 mg/dL

0050355 Immunoglobulin M Effective February 16, 2021
0-2 years: 21-215 mg/dL                     
3-4 years: 26-155 mg/dL                                
5-9 years: 26-188 mg/dL                          
10-14 years: 47-252 mg/dL                               
15-18 years: 26-232 mg/dL
19 years and older: 35-263 mg/dL

  Total Protein, Serum August 19,2019
Refer to Report
  Asialo-GM1 Antibodies, IgG/IgM
29 IV or less Negative
30-50 IV Equivocal
51-100 IV Positive
101 IV or greater Strong Positive

  GM1 Antibodies, IgG/IgM
29 IV or less Negative
30-50 IV Equivocal
51-100 IV Positive
101 IV or greater Strong Positive

  GD1a Antibodies, IgG/IgM
29 IV or less Negative
30-50 IV Equivocal
51-100 IV Positive
101 IV or greater Strong Positive

  GD1b Antibodies, IgG/IgM
29 IV or less Negative
30-50 IV Equivocal
51-100 IV Positive
101 IV or greater Strong Positive

  GQ1b Antibodies, IgG/IgM
29 IV or less Negative
30-50 IV Equivocal
51-100 IV Positive
101 IV or greater Strong Positive

0051284 Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibody, IgM Less than 1.00 IV
0051285 Myelin Associated Glycoprotein (MAG) Antibody, IgM Less than 1000 TU
2007961 Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot Effective August 17, 2020
Test Number
 Components
 Reference Interval
Purkinje Cell/Neuronal Nuclear IgG Scrn None Detected
Neuronal Nuclear Antibody (ANNA) IFA Titer, IgG Less than 1:10
Purkinje Cell Antibody, Titer Less than 1:10
3002917 Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot, Serum Refer to report

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/16/2021
X
X
X
08/17/2020
X
X
X
X
08/19/2019
X
X
X
X
X
N/A
CPT Codes

83516 x7; 82784 x3; 84155; 84165; 86334; 86255 if reflexed add 84182 x4 and/or 86256

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Components
Component Test Code* Component Chart Name LOINC
0050020 Albumin 2862-1
0050035 Alpha 1 Globulin 2865-4
0050060 Alpha 2 Globulin 2868-8
0050110 Beta Globulin 2871-2
0050270 Gamma 2874-6
0050271 Immunofixation 25700-6
0050340 Immunoglobulin A 2458-8
0050350 Immunoglobulin G 2465-3
0050355 Immunoglobulin M 2472-9
0050545 Total Protein, Serum 2885-2
0051034 Asialo-GM1 Antibodies, IgG/IgM 88723-2
0051035 GM1 Antibodies, IgG/IgM 31500-2
0051037 GD1a Antibodies, IgG/IgM 88724-0
0051038 GD1b Antibodies, IgG/IgM 88730-7
0051039 GQ1b Antibodies, IgG/IgM 88729-9
0051284 SGPG Antibody, IgM 31666-1
0051285 MAG Antibody, IgM Elisa 17314-6
2005168 SPEP/IFE Interpretation 49275-1
2007962 Purkinje Cell/Neuronal Nuclear IgG Scrn 61177-2
2012458 EER Motor Sensory Neuropathy Comp
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Motor and Sensory Neuropathy Evaluation with Immunofixation Electrophoresis and Reflex to Titer and Neuronal Immunoblot