Ordering Recommendation

Aid in diagnosis of combined motor/sensory neuropathy when malignancy, other than plasma cell dyscrasia, is suspected.

Mnemonic
MSNER
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot

Performed

Thu

Reported

1-9 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions

Plasma, CSF, or other body fluids. Contaminated, heat-inactivated, hemolyzed, severely icteric, or lipemic specimens.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval
Test Number
Components
Reference Interval
  Asialo-GM1 Antibodies, IgG/IgM
29 IV or less Negative
30-50 IV Equivocal
51-100 IV Positive
101 IV or greater Strong Positive

  GM1 Antibodies, IgG/IgM
29 IV or less Negative
30-50 IV Equivocal
51-100 IV Positive
101 IV or greater Strong Positive

  GD1a Antibodies, IgG/IgM
29 IV or less Negative
30-50 IV Equivocal
51-100 IV Positive
101 IV or greater Strong Positive

  GD1b Antibodies, IgG/IgM
29 IV or less Negative
30-50 IV Equivocal
51-100 IV Positive
101 IV or greater Strong Positive

  GQ1b Antibodies, IgG/IgM
29 IV or less Negative
30-50 IV Equivocal
51-100 IV Positive
101 IV or greater Strong Positive

0051284 Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibody, IgM Less than 1.00 IV
0051285 Myelin Associated Glycoprotein (MAG) Antibody, IgM Less than 1000 TU
2007961 Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot Effective August 17, 2020
Test Number
Components
Reference Interval
Purkinje Cell/Neuronal Nuclear IgG Scrn None Detected
Neuronal Nuclear Antibody (ANNA) IFA Titer, IgG Less than 1:10
Purkinje Cell Antibody, Titer Less than 1:10
3002917 Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot, Serum Refer to report

Interpretive Data



Compliance Category

Laboratory Developed Test (LDT)

Note

Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. Additional charges apply.

Hotline History
N/A
CPT Codes

83516 x7; 86255; if reflexed add 84182 x4 and/or 86256

Components
Component Test Code* Component Chart Name LOINC
0051034 Asialo-GM1 Antibodies, IgG/IgM 88723-2
0051035 GM1 Antibodies, IgG/IgM 31500-2
0051037 GD1a Antibodies, IgG/IgM 88724-0
0051038 GD1b Antibodies, IgG/IgM 88730-7
0051039 GQ1b Antibodies, IgG/IgM 88729-9
0051284 SGPG Antibody, IgM 31666-1
0051285 MAG Antibody, IgM Elisa 17314-6
2007962 Purkinje Cell/Neuronal Nuclear IgG Scrn 61177-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Motor and Sensory Neuropathy Evaluation with Reflex to Titer and Neuronal Immunoblot