Ordering Recommendation

Aid in diagnosis of a sensory neuropathy when malignancy, other than plasma cell dyscrasia, is suspected.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Serum separator tube

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature


Unacceptable Conditions

Other body fluids. Contaminated, heat-inactivated, hemolyzed, grossly icteric, or lipemic specimens.


After separation from cells: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 year


Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot




2-9 days

Reference Interval

Test Number
Reference Interval
  SGPG Antibody, IgM Less than 1.00 IV
  MAG Antibody, IgM Elisa Less than 1000 TU
  Purkinje Cell/Neuronal Nuclear IgG Scrn None Detected

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. Additional charges apply.

Hotline History


CPT Codes

83516 x2; 86255; if reflexed add 84182 x4 and/or 86256


Component Test Code* Component Chart Name LOINC
0051284 SGPG Antibody, IgM 31666-1
0051285 MAG Antibody, IgM Elisa 17314-6
2007962 Purkinje Cell/Neuronal Nuclear IgG Scrn 61177-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • ANNA IgG
  • MAG IgM
  • Neuronal Nucelar IgG Abs
  • Purkinje Cell IgG Screen
  • Purkinje Cell Titer
  • SGPG IgM
Sensory Neuropathy Antibody Panel with Reflex to Titer and Neuronal Immunoblot