Ordering Recommendation

Aid in diagnosis of a sensory neuropathy when malignancy, other than plasma cell dyscrasia, is suspected.

Mnemonic
SNAP R
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot

Performed

Refer to individual components

Reported

2-9 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Other body fluids. Contaminated, heat-inactivated, hemolyzed, grossly icteric, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval
Test Number
Components
Reference Interval
Purkinje Cell/Neuronal Nuclear IgG Scrn None Detected
Neuronal Nuclear Antibody (ANNA) IFA Titer, IgG Less than  1:10
Purkinje Cell Antibody, Titer Less than  1:10
3002917 Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot, Serum
Test Number
Components
Reference Interval
  Neuronal Nuclear Ab (Yo) IgG, IB, Serum Refer to report
  Neuronal Nuclear Ab (TR/DNER) IgG, IB Refer to report
  Neuronal Nuclear Ab (Ri) IgG, IB, Serum Refer to report
  Neuronal Nuclear Ab (Hu) IgG, IB, Serum Refer to report

0051285 Myelin Associated Glycoprotein (MAG) Antibody, IgM Less than 1000 TU
0051284 Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibody, IgM Less than 1.00 IV

Interpretive Data



Compliance Category

Laboratory Developed Test (LDT)

Note

Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. Additional charges apply.

Hotline History
N/A
CPT Codes

83516 x2; 86255; if reflexed add 84182 x4 and/or 86256

Components
Component Test Code* Component Chart Name LOINC
0051284 SGPG Antibody, IgM 31666-1
0051285 MAG Antibody, IgM Elisa 17314-6
2007962 Purkinje Cell/Neuronal Nuclear IgG Scrn 61177-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ANNA IgG
  • MAG IgM
  • Neuronal Nucelar IgG Abs
  • Purkinje Cell IgG Screen
  • Purkinje Cell Titer
  • SGPG IgM
Sensory Neuropathy Antibody Panel with Reflex to Titer and Neuronal Immunoblot