Ordering Recommendation

Aid in the diagnosis of paraneoplastic neurologic syndromes associated with malignancy. Order based on clinical presentation.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Serum separator tube

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.75 mL)

Storage/Transport Temperature


Unacceptable Conditions

Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.


After separation from cells: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 year


Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot


Sun, Wed, Fri


1-6 days

Reference Interval

Test Number
Reference Interval
  Purkinje Cell/Neuronal Nuclear IgG Scrn None Detected

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. Additional charges apply.

Hotline History


CPT Codes

86255; if reflexed add 84182 x4 and/or 86256


Component Test Code* Component Chart Name LOINC
2007962 Purkinje Cell/Neuronal Nuclear IgG Scrn 61177-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • ANNA
  • ANNA-1
  • ANNA-2
  • Anti Ri
  • Anti-Hu
  • Anti-Yo
  • Antinuclear neuronal Ab
  • Neuronal Nuclear Antibody
  • Paraneoplastic Ab screen
  • Paraneoplastic Autoantibody Immunoblot Confirmation, Paraneoplastic Neurological Autoimmunity
  • PCA-1
  • PCA-3
  • PCA-Tr
  • Purkinje Cell Cytoplasmic Antibodies
  • Tr(DNER)
PCCA/ANNA by IFA with Reflex to Titer and Immunoblot