Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot
Aid in the diagnosis of paraneoplastic neurologic syndromes associated with malignancy. Order based on clinical presentation.
Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot
Sun, Wed, Fri
Serum separator tube
Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.75 mL)
Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
After separation from cells: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 year
Effective August 17, 2020
|Purkinje Cell/Neuronal Nuclear IgG Scrn||None Detected|
|Neuronal Nuclear Antibody (ANNA) IFA Titer, IgG||Less than 1:10|
|Purkinje Cell Antibody, Titer||Less than 1:10|
|3002917||Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot, Serum||
Laboratory Developed Test (LDT)
Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. Additional charges apply.
86255; if reflexed add 84182 x4 and/or 86256
|Component Test Code*||Component Chart Name||LOINC|
|2007962||Purkinje Cell/Neuronal Nuclear IgG Scrn||61177-2|
- Anti Ri
- Antinuclear neuronal Ab
- Neuronal Nuclear Antibody
- Paraneoplastic Ab screen
- Paraneoplastic Autoantibody Immunoblot Confirmation, Paraneoplastic Neurological Autoimmunity
- Purkinje Cell Cytoplasmic Antibodies