Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot

2007961
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Example Reports
Detected
None Detected

Ordering Recommendation

Aid in the diagnosis of paraneoplastic neurologic syndromes associated with malignancy. Order based on clinical presentation.

Mnemonic

PCCA/ANNA

Methodology

Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot

Performed

Sun, Wed, Fri

Reported

1-6 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.75 mL)

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions

Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

Effective August 17, 2020

Test Number
 Components
 Reference Interval
Purkinje Cell/Neuronal Nuclear IgG Scrn None Detected
Neuronal Nuclear Antibody (ANNA) IFA Titer, IgG Less than 1:10
Purkinje Cell Antibody, Titer Less than 1:10
3002917 Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot, Serum
Test Number
 Components
 Reference Interval
  Neuronal Nuclear Ab (Yo) IgG, IB, Serum Refer to report
  Neuronal Nuclear Ab (TR/DNER) IgG, IB Refer to report
  Neuronal Nuclear Ab (Ri) IgG, IB, Serum Refer to report
  Neuronal Nuclear Ab (Hu) IgG, IB, Serum Refer to report

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be added. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/17/2020
X
X
X
X
N/A

CPT Codes

86255; if reflexed add 84182 x4 and/or 86256

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Components

Component Test Code* Component Chart Name LOINC
2007962 Purkinje Cell/Neuronal Nuclear IgG Scrn 61177-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • ANNA
  • ANNA-1
  • ANNA-2
  • Anti Ri
  • Anti-Hu
  • Anti-Yo
  • Antinuclear neuronal Ab
  • Neuronal Nuclear Antibody
  • Paraneoplastic Ab screen
  • Paraneoplastic Autoantibody Immunoblot Confirmation, Paraneoplastic Neurological Autoimmunity
  • PCA-1
  • Purkinje Cell Cytoplasmic Antibodies
Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot