Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
VENLAFAXSP
Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Wed, Sat

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Pre-dose (trough) draw - At steady state concentration.

Collect

Lavender (EDTA), Pink (K2EDTA), or Plain Red.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD Solution).

Remarks
Stability

Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: 2 weeks

Reference Interval
Therapeutic range - Total (venlafaxine and o-desmethylvenlafaxine) 195-400 ng/mL
Toxic range Not well established

Interpretive Data

The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Adverse effects to venlafaxine therapy may include nausea, vomiting, dizziness, tremor and blurred vision.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

80338 (Alt code: G0480)

Components
Component Test Code* Component Chart Name LOINC
2007958 Venlafaxine Serum/Plasma 9630-5
2007959 O-Desmethylvenlafaxine Serum/Plasma 9628-9
2007960 Total Venlafaxine and Metabolite S/P 62849-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Effexor
  • Effexor XR
  • Pristiq
Venlafaxine and Metabolite, Serum or Plasma