Human Papillomavirus (HPV), High Risk by Transcription-Mediated Amplification (TMA) with Reflex to HPV Genotypes 16 and 18/45 by TMA, ThinPrep
FDA-approved test for routine cervical cancer screening in combination with cervical cytology (Pap smear) in women ≥30 years; genotyping performed for triaging women to colposcopy who are cytology-negative (NILM) and HPV-positive.
Qualitative Transcription-Mediated Amplification
Females should avoid high concentrations of antifungal cream or contraceptive jelly, and should not douche prior to time of collection.
Cervical specimen with the ThinPrep Pap Test Collection kit.
Vortex ThinPrep PreservCyt solution and transfer 1 mL to an APTIMA Specimen Transfer Tube (ARUP supply #42711) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.
Specimens in any media other than indicated above.
Specimen source required.
ThinPrep PreservCyt solution: Ambient: 1 month; Refrigerated: 1 month; Frozen: 2 years
APTIMA Specimen Transfer Tube: Ambient: 2 months; Refrigerated: 2 months; Frozen: 2 years
This test detects E6/E7 viral messenger RNA of the high-risk HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 associated with cervical cancer and its precursor lesions. Cross-reactivity with low-risk HPV genotypes 26, 67, 70, and 82 may occur. Sensitivity may be affected by specimen collection methods, stage of infection, and the presence of interfering substances. Results should be interpreted in conjunction with other available laboratory and clinical data.
This test is intended for medical purposes only and is not valid for the evaluation of suspected sexual abuse or for other forensic purposes. HPV testing should not be used for screening or management of atypical squamous cells of undetermined significance (ASCUS) in women under age 21.
If Human Papillomavirus (HPV), High Risk is positive, then HPV genotypes 16, 18/45 will be added. Additional charges apply.
No compliance statements are in use for this test.
87624; if reflexed, add 87625
|Component Test Code*||Component Chart Name||LOINC|
|2007891||HPV, High Risk by TMA||49896-4|
- HPV genotype
- HPV HR E6/E7 reflex to 16 and 18/45
- HPV HR reflex to genotyping
- HPV mRNA reflex
- Nucleic Acid Amplification Test (NAAT)