Ordering Recommendation
Preferred test to follow-up presumptive results or for monitoring compliance. To optimize drug therapy, Tricyclic Antidepressants, Quantitative, Serum or Plasma (2007549) is preferred.
Mnemonic
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Tue, Thu, Sat
Reported
1-5 days
New York DOH Approval Status
Specimen Required
Random urine.
Transfer 2 mL urine to ARUP Standard Transport Tube. (Min: 0.7 mL)
Refrigerated.
Ambient: 1 week; Refrigerated: 11 days; Frozen: 2 weeks
Reference Interval
Interpretive Data
Interpretive Data: Interpretive comments: Urine concentrations of tricyclic antidepressants do not correlate with signs or symptoms of therapy or toxicity.
Therapeutic ranges are not established.
100 ng/mL limit of quantification: Amitriptyline, Nortriptyline, Imipramine, Desipramine, Doxepin, Nordoxepin, Protriptyline
200 ng/mL limit of quantification: Clomipramine, Norclomipramine
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
This test is used to quantitate the following tricyclic antidepressants: amitriptyline, clomipramine, desipramine, doxepin, imipramine, norclomipramine, nordoxepin, nortriptyline and protriptyline.
Hotline History
CPT Codes
80337 (Alt code: G0480)
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2007516 | Amitriptyline, Quant, Urn | 16114-1 |
2007517 | Nortriptyline, Quant, Urn | 3875-2 |
2007518 | Amitriptyline/Nortriptyline Total, Urn | 10978-5 |
2007519 | Imipramine Quant, Urn | 3692-1 |
2007520 | Desipramine Quant, Urn | 3534-5 |
2007521 | Imipramine/Desipramine Total, Urn | |
2007522 | Doxepin Quant, Urn | 3581-6 |
2007523 | Nordoxepin Quant, Urn | 12386-9 |
2007524 | Doxepin/Nordoxepin Total, Urn | 19247-6 |
2007525 | Protriptyline Quant, Urn | 26978-7 |
2007526 | Clomipramine Quant, Urn | 3492-6 |
2007527 | Norclomipramine Quant, Urn | 18470-5 |
2007528 | Clomipramine/Norclomipramine Total, Urn | 91606-4 |
Aliases
- Quantitative Antidepressant Drug Screen
- TCA Screen
- Tricyclic Screen