Ordering Recommendation

Preferred test to follow-up presumptive results or for monitoring compliance. To optimize drug therapy, Tricyclic Antidepressants, Quantitative, Serum or Plasma (2007549) is preferred.


Quantitative Liquid Chromatography-Tandem Mass Spectrometry


Tue, Thu, Sat


1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Random urine.

Specimen Preparation

Transfer 2 mL urine to ARUP Standard Transport Tube. (Min: 0.7 mL)

Storage/Transport Temperature


Unacceptable Conditions

Ambient: 1 week; Refrigerated: 11 days; Frozen: 2 weeks

Reference Interval

Interpretive Data

Interpretive Data: Interpretive comments: Urine concentrations of tricyclic antidepressants do not correlate with signs or symptoms of therapy or toxicity.
Therapeutic ranges are not established.
100 ng/mL limit of quantification: Amitriptyline, Nortriptyline, Imipramine, Desipramine, Doxepin, Nordoxepin, Protriptyline
200 ng/mL limit of quantification: Clomipramine, Norclomipramine

Compliance Category

Laboratory Developed Test (LDT)


This test is used to quantitate the following tricyclic antidepressants: amitriptyline, clomipramine, desipramine, doxepin, imipramine, norclomipramine, nordoxepin, nortriptyline and protriptyline.

Hotline History
CPT Codes

80337 (Alt code: G0480)

Component Test Code* Component Chart Name LOINC
2007516 Amitriptyline, Quant, Urn 16114-1
2007517 Nortriptyline, Quant, Urn 3875-2
2007518 Amitriptyline/Nortriptyline Total, Urn 10978-5
2007519 Imipramine Quant, Urn 3692-1
2007520 Desipramine Quant, Urn 3534-5
2007521 Imipramine/Desipramine Total, Urn
2007522 Doxepin Quant, Urn 3581-6
2007523 Nordoxepin Quant, Urn 12386-9
2007524 Doxepin/Nordoxepin Total, Urn 19247-6
2007525 Protriptyline Quant, Urn 26978-7
2007526 Clomipramine Quant, Urn 3492-6
2007527 Norclomipramine Quant, Urn 18470-5
2007528 Clomipramine/Norclomipramine Total, Urn 91606-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Quantitative Antidepressant Drug Screen
  • TCA Screen
  • Tricyclic Screen
Tricyclic Antidepressants, Quantitative, Urine