Tricyclic Antidepressants, Quantitative, Urine
Ordering Recommendation
Preferred test to follow up a presumptive result or monitor compliance. To optimize dosing, the preferred test is Tricyclic Antidepressants, Quantitative, Serum or Plasma (2007549).
New York DOH Approval Status
Specimen Required
Random urine.
Transfer 2 mL urine to ARUP standard transport tube. (Min: 0.7 mL)
Refrigerated.
Ambient: 1 week; Refrigerated: 11 days; Frozen: 2 weeks
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun
Reported
2-8 days
Reference Interval
Interpretive Data
Urine concentrations of tricyclic antidepressants do not correlate with signs or symptoms of therapy or toxicity.
Therapeutic ranges are not established.
100 ng/mL limit of quantification: Amitriptyline, nortriptyline, imipramine, desipramine, doxepin, nordoxepin, protriptyline
200 ng/mL limit of quantification: Clomipramine, norclomipramine
Laboratory Developed Test (LDT)
Note
This test is used to quantitate the following tricyclic antidepressants: amitriptyline, clomipramine, desipramine, doxepin, imipramine, norclomipramine, nordoxepin, nortriptyline, and protriptyline.
Hotline History
Hotline History
CPT Codes
80337 (Alt code: G0480)
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2007516 | Amitriptyline, Quant, Urn | 16114-1 |
2007517 | Nortriptyline, Quant, Urn | 3875-2 |
2007519 | Imipramine Quant, Urn | 3692-1 |
2007520 | Desipramine Quant, Urn | 3534-5 |
2007522 | Doxepin Quant, Urn | 3581-6 |
2007523 | Nordoxepin Quant, Urn | 12386-9 |
2007525 | Protriptyline Quant, Urn | 26978-7 |
2007526 | Clomipramine Quant, Urn | 3492-6 |
2007527 | Norclomipramine Quant, Urn | 18470-5 |
Aliases
- Quantitative Antidepressant Drug Screen
- TCA Screen
- Tricyclic Screen