Ordering Recommendation

Preferred test to follow-up presumptive results or for monitoring compliance. To optimize drug therapy, Tricyclic Antidepressants, Quantitative, Serum or Plasma (2007549) is preferred.




Quantitative Liquid Chromatography-Tandem Mass Spectrometry


Tue, Thu, Sat


1-5 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Random urine.

Specimen Preparation

Transfer 2 mL urine to ARUP Standard Transport Tube. (Min: 0.7 mL)

Storage/Transport Temperature


Unacceptable Conditions

Ambient: 1 week; Refrigerated: 11 days; Frozen: 2 weeks

Reference Interval

Interpretive Data

Interpretive Data: Interpretive comments: Urine concentrations of tricyclic antidepressants do not correlate with signs or symptoms of therapy or toxicity.
Therapeutic ranges are not established.
100 ng/mL limit of quantification: Amitriptyline, Nortriptyline, Imipramine, Desipramine, Doxepin, Nordoxepin, Protriptyline
200 ng/mL limit of quantification: Clomipramine, Norclomipramine

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


This test is used to quantitate the following tricyclic antidepressants: amitriptyline, clomipramine, desipramine, doxepin, imipramine, norclomipramine, nordoxepin, nortriptyline and protriptyline.

Hotline History


CPT Codes

80337 (Alt code: G0480)


Component Test Code* Component Chart Name LOINC
2007516 Amitriptyline, Quant, Urn 16114-1
2007517 Nortriptyline, Quant, Urn 3875-2
2007518 Amitriptyline/Nortriptyline Total, Urn 10978-5
2007519 Imipramine Quant, Urn 3692-1
2007520 Desipramine Quant, Urn 3534-5
2007521 Imipramine/Desipramine Total, Urn
2007522 Doxepin Quant, Urn 3581-6
2007523 Nordoxepin Quant, Urn 12386-9
2007524 Doxepin/Nordoxepin Total, Urn 19247-6
2007525 Protriptyline Quant, Urn 26978-7
2007526 Clomipramine Quant, Urn 3492-6
2007527 Norclomipramine Quant, Urn 18470-5
2007528 Clomipramine/Norclomipramine Total, Urn 91606-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Quantitative Antidepressant Drug Screen
  • TCA Screen
  • Tricyclic Screen
Tricyclic Antidepressants, Quantitative, Urine